UniProt Accession

 PARPT_HUMAN; Q7Z3E1; D3DNK6; Q68CY9; Q86VP4; Q9Y4P7 

Genbank Protein ID

 AL080156; BX537965; CR749647; CH471052; CH471052; BC050350 

Genbank Nucleotide ID

 CAB45747.2; CAD97929.1; CAH18441.1; EAW78725.1; EAW78728.1; AAH50350.2 

Protein Name

 TCDD-inducible poly [ADP-ribose] polymerase 

Protein Synonyms/Alias

 ADP-ribosyltransferase diphtheria toxin-like 14; ARTD14; Poly [ADP-ribose] polymerase 7; PARP-7 

Gene Name

 TIPARP 

Gene Synonyms/Alias

 PARP7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	IKRTTTQKWQSVFND	ubiquitination	[1]
544	DVVDGICKHNFDPRV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity). 

Sequence Annotation

 DOMAIN 332 410 WWE.
 DOMAIN 449 657 PARP catalytic.
 ZN_FING 237 264 C3H1-type.  

Keyword

 Complete proteome; Glycosyltransferase; Metal-binding; NAD; Polymorphism; Reference proteome; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 657 AA 

Protein Sequence

Gene Ontology

 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008209; P:androgen metabolic process; IEA:Compara.
 GO:0008210; P:estrogen metabolic process; IEA:Compara.
 GO:0060325; P:face morphogenesis; IEA:Compara.
 GO:0008585; P:female gonad development; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0044236; P:multicellular organismal metabolic process; IEA:Compara.
 GO:0006807; P:nitrogen compound metabolic process; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006471; P:protein ADP-ribosylation; IEA:Compara.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara.
 GO:0001570; P:vasculogenesis; IEA:Compara. 

Interpro

 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004170; WWE-dom.
 IPR000571; Znf_CCCH. 

Pfam

 PF00644; PARP 

SMART

  

PROSITE

 PS51059; PARP_CATALYTIC
 PS50918; WWE
 PS50103; ZF_C3H1 

PRINTS