UniProt Accession

 K7EIG1_HUMAN; K7EIG1 

Genbank Protein ID

 AC005696 

Genbank Nucleotide ID

  

Protein Name

 Clustered mitochondria protein homolog 

Protein Synonyms/Alias

  

Gene Name

 CLUH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
907	VVKHVNPKASDAFHF	ubiquitination	[1, 2]
921	FFQSGQAKVQQGFLK	ubiquitination	[3]
1092	VARVYESKAEFRSAL	ubiquitination	[2]
1103	RSALQHEKEGYTIYK	acetylation	[4]
1128	KESSEYLKCLTQQAV	ubiquitination	[2]
1190	QKDLENLKAEVARRH	ubiquitination	[3, 5, 6, 7]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Involved in proper cytoplasmic distribution of mitochondria (By similarity). 

Sequence Annotation

 REPEAT 911 944 TPR 1 (By similarity).
 REPEAT 953 986 TPR 2 (By similarity).
 REPEAT 1037 1070 TPR 3 (By similarity).
 REPEAT 1079 1112 TPR 4 (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1242 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0048312; P:intracellular distribution of mitochondria; IEA:InterPro. 

Interpro

 IPR027523; CLU.
 IPR025697; CLU_dom.
 IPR023231; GSKIP/TIF31_domain.
 IPR011990; TPR-like_helical. 

Pfam

 PF13236; CLU 

SMART

  

PROSITE

  

PRINTS