UniProt Accession

 NDK8_HUMAN; O60361 

Genbank Protein ID

 AC004263 

Genbank Nucleotide ID

 AAC05177.1 

Protein Name

 Putative nucleoside diphosphate kinase 

Protein Synonyms/Alias

 NDK; NDP kinase 

Gene Name

 NME2P1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	PASEEHLKQHYIDLK	acetylation	[1]
41	KQHYIDLKDRPFFPG	acetylation	[1]
70	WEGLNVVKTGRVMLG	acetylation	[1]
70	WEGLNVVKTGRVMLG	ubiquitination	[2]
85	ETNPADSKPGTIRGD	acetylation	[1]
109	IHGSDSVKSAEKEIS	acetylation	[1]
109	IHGSDSVKSAEKEIS	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). 

Sequence Annotation

 ACT_SITE 103 103 Pros-phosphohistidine intermediate (By
 BINDING 45 45 ATP (By similarity).
 BINDING 73 73 ATP (By similarity).
 BINDING 79 79 ATP (By similarity).
 BINDING 90 90 ATP (By similarity).
 BINDING 100 100 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.