UniProt Accession

 MP3B2_HUMAN; A6NCE7 

Genbank Protein ID

 DN994744; AC125603; CH471054 

Genbank Nucleotide ID

 EAW98085.1 

Protein Name

 Microtubule-associated proteins 1A/1B light chain 3 beta 2 

Protein Synonyms/Alias

 Microtubule-associated proteins 1A/1B light chain 3B-like 

Gene Name

 MAP1LC3B2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	LPVLDKTKFLVPDHV	ubiquitination	[1, 2]
65	VNMSELIKIIRRRLQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). 

Sequence Annotation

 LIPID 120 120 Phosphatidylethanolamine amidated glycine  

Keyword

 Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Lipoprotein; Membrane; Microtubule; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 125 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS