CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031038
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DnaJ homolog subfamily B member 6 
Protein Synonyms/Alias
 cDNA FLJ51000, highly similar to DnaJ homolog subfamily B member 6 
Gene Name
 DNAJB6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18KKRDIYDKYGKEGLNubiquitination[1, 2, 3, 4, 5]
21DIYDKYGKEGLNGGGubiquitination[3, 4]
147KSISTSTKMVNGRKIubiquitination[1, 2, 4, 5, 6]
176VEEDGQLKSLTINGVubiquitination[4]
253LASAAGLKEGGKRKKubiquitination[2, 3, 5, 6, 7]
257AGLKEGGKRKKQKQRubiquitination[6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 277 AA 
Protein Sequence
MPHPRILKRP KKRDIYDKYG KEGLNGGGGG GSHFDSPFEF GFTFRNPDDV FREFFGGRDP 60
FSFDFFEDPF EDFFGNRRGP RGSRSRGTGS FFSAFSGFPS FGSGFSSFDT GFTSFGSLGH 120
GGLTSFSSTS FGGSGMGNFK SISTSTKMVN GRKITTKRIV ENGQERVEVE EDGQLKSLTI 180
NGVADDDALA EERMRRGQNA LPAQPAGLRP PKPPRPASLL RHAPHCLSEE EGEQDRPRAP 240
GPWDPLASAA GLKEGGKRKK QKQREESKKK KSTKGNH 277 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS