| Tag | Content |
|---|
| CPLM ID | CPLM-016077 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein VAC14 homolog |
Protein Synonyms/Alias | |
Gene Name | Vac14 |
Gene Synonyms/Alias | D8Wsu151e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 170 | DIVTESSKFDLVSFI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. |
Sequence Annotation | REPEAT 5 42 HEAT 1.
REPEAT 89 126 HEAT 2.
REPEAT 171 208 HEAT 3.
REPEAT 212 249 HEAT 4.
REPEAT 438 475 HEAT 5.
REPEAT 560 598 HEAT 6.
REGION 773 777 Mediates interaction with the PDZ domain
MOD_RES 11 11 Phosphothreonine (By similarity).
MOD_RES 499 499 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Disease mutation; Endoplasmic reticulum; Endosome; Membrane; Microsome; Neurodegeneration; Neuropathy; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 782 AA |
Protein Sequence | MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVRDF VAQNNTMQIK HVIQTLSQEF 60
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDADSRLR YYACEALYNI 120
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESSK FDLVSFIPLL 180
RERIYSNNQY ARQFIISWIL VLVSVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL 240
GEFLKEIKKN PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 300
LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDEPD EPKSVAQKQT EPNPEDSLPK 360
QEGTASGGPG SCDSSFGSGI NVFTSANTDR APVTLHLDGI VQVLNCHLSD TTIGMMTRIA 420
VLKWLYHLYI KTPRKMFRHT DSLFPILLQT LSDESDEVVL KDLEVLAEIA SSPAGQTDDP 480
GAPDGPDLRV NHSELQVPTS GRANLLNPPS TKGLEGSPST PTMNSYFYKF MINLLQTFSS 540
ERKLLEARGP FIIRQLCLLL NAENIFHSMA DILLREEDLK FASTMVHTLN TILLTSTELF 600
QLRNQLKDLQ TPESQNLFCC LYRSWCHNPV TTVSLCFLTQ NYRHAYDLIQ KFGDLEVTVD 660
FLTEVDKLVQ LIECPIFTYL RLQLLDVKNN PYLIKALYGL LMLLPQSSAF QLLSHRLQCV 720
PNPELLQTED CLKAAPKSQK GDSPSIDYTE LLQHFEKVQK QHLEVRHQRS GRGDHLDRRV 780
IL 782 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |