| Tag | Content |
|---|
| CPLM ID | CPLM-003803 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase F |
Protein Synonyms/Alias | Leukocyte common antigen related; LAR |
Gene Name | PTPRF |
Gene Synonyms/Alias | LAR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1286 | RTHSPSSKDEQSIGL | ubiquitination | [1] | | 1294 | DEQSIGLKDSLLAHS | ubiquitination | [1] | | 1801 | WPEQGVPKTGEGFID | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). |
Sequence Annotation | DOMAIN 33 123 Ig-like C2-type 1.
DOMAIN 135 224 Ig-like C2-type 2.
DOMAIN 232 314 Ig-like C2-type 3.
DOMAIN 319 407 Fibronectin type-III 1.
DOMAIN 413 506 Fibronectin type-III 2.
DOMAIN 512 602 Fibronectin type-III 3.
DOMAIN 606 703 Fibronectin type-III 4.
DOMAIN 708 815 Fibronectin type-III 5.
DOMAIN 817 910 Fibronectin type-III 6.
DOMAIN 915 1008 Fibronectin type-III 7.
DOMAIN 1011 1095 Fibronectin type-III 8.
DOMAIN 1352 1607 Tyrosine-protein phosphatase 1.
DOMAIN 1639 1898 Tyrosine-protein phosphatase 2.
REGION 68 77 Heparin-binding (By similarity).
REGION 1548 1554 Substrate binding (By similarity).
ACT_SITE 1548 1548 Phosphocysteine intermediate (Probable).
ACT_SITE 1839 1839 Phosphocysteine intermediate (By
BINDING 1516 1516 Substrate (By similarity).
BINDING 1592 1592 Substrate (By similarity).
CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
CARBOHYD 250 250 N-linked (GlcNAc...) (Potential).
CARBOHYD 295 295 N-linked (GlcNAc...) (Potential).
CARBOHYD 721 721 N-linked (GlcNAc...) (Potential).
CARBOHYD 959 959 N-linked (GlcNAc...); atypical.
CARBOHYD 966 966 N-linked (GlcNAc...).
DISULFID 54 107 By similarity.
DISULFID 156 207 By similarity.
DISULFID 253 298 By similarity. |
Keyword | 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Heparin-binding; Hydrolase; Immunoglobulin domain; Membrane; Polymorphism; Protein phosphatase; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1907 AA |
Protein Sequence | MAPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA SFVCQATGEP 60
KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120
KLSVLEEEQL PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS 180
NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240
QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 300
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY GIQYRAAGTE 360
GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420
QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP 480
GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI 540
IMYELVYWAA EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR 600
TAQSTPSAPP QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD GEDRGRHVVD 660
GISREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720
NSTAVHVYWK LPVPSKQHGQ IRGYQVTYVR LENGEPRGLP IIQDVMLAEA QETTISGLTP 780
ETTYSVTVAA YTTKGDGARS KPKIVTTTGA VPGRPTMMIS TTAMNTALLQ WHPPKELPGE 840
LLGYRLQYCR ADEARPNTID FGKDDQHFTV TGLHKGTTYI FRLAAKNRAG LGEEFEKEIR 900
TPEDLPSGFP QNLHVTGLTT STTELAWDPP VLAERNGRII SYTVVFRDIN SQQELQNITT 960
DTRFTLTGLK PDTTYDIKVR AWTSKGSGPL SPSIQSRTMP VEQVFAKNFR VAAAMKTSVL 1020
LSWEVPDSYK SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH 1080
LVSIRTAPDL LPHKPLPASA YIEDGRFDLS MPHVQDPSLV RWFYIVVVPI DRVGGSMLTP 1140
RWSTPEELEL DELLEAIEQG GEEQRRRRRQ AERLKPYVAA QLDVLPETFT LGDKKNYRGF 1200
YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL 1260
AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH 1320
PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNLEVNKPKN RYANVIAYDH 1380
SRVILTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM 1440
TRLEEKSRVK CDQYWPARGT ETCGLIQVTL LDTVELATYT VRTFALHKSG SSEKRELRQF 1500
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK 1560
HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAT CGHTEVPARN LYAHIQKLGQ 1620
VPPGESVTAM ELEFKLLASS KAHTSRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV 1680
EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC 1740
HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ 1860
TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |