UniProt Accession

 U119A_HUMAN; Q13432; A8K8G4; F1T095; O95126 

Genbank Protein ID

 U40998; AF028788; AF028789; AF125998; AF125997; AK292329; AB593014; AC005726; CH471159; BC027176 

Genbank Nucleotide ID

 AAC50360.1; AAD01875.1; AAD01876.1; AAD31422.1; AAD31422.1; BAF85018.1; BAJ83969.1; EAW51095.1; AAH27176.1 

Protein Name

 Protein unc-119 homolog A 

Protein Synonyms/Alias

 Retinal protein 4; hRG4 

Gene Name

 UNC119 

Gene Synonyms/Alias

 RG4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	RPGPLQRKQPIGPED	ubiquitination	[1]
85	SPEENIYKIDFVRFK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G- protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. 

Sequence Annotation

 BINDING 131 131 Lipid.
 MOD_RES 37 37 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cone-rod dystrophy; Cytoplasm; Cytoskeleton; Lipid-binding; Phosphoprotein; Protein transport; Reference proteome; Sensory transduction; Transport; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 240 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:ProtInc.
 GO:0008289; F:lipid binding; IDA:UniProtKB.
 GO:0042953; P:lipoprotein transport; IDA:UniProtKB.
 GO:0007602; P:phototransduction; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR008015; GMP_PDE_delta.
 IPR014756; Ig_E-set. 

Pfam

 PF05351; GMP_PDE_delta 

SMART

  

PROSITE

  

PRINTS