UniProt Accession

 DBNL_HUMAN; Q9UJU6; A4D2I9; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72 

Genbank Protein ID

 AF197060; AF077353; AF250287; AF151364; AF218020; AK027367; CR457167; CH236960; CH471128; BC011677; BC031687 

Genbank Nucleotide ID

 AAF13701.1; AAF80228.1; AAF81273.1; AAG13120.1; AAG17262.2; BAB55065.1; CAG33448.1; EAL23770.1; EAW61132.1; AAH11677.1; AAH31687.1 

Protein Name

 Drebrin-like protein 

Protein Synonyms/Alias

 Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7 

Gene Name

 DBNL 

Gene Synonyms/Alias

 CMAP; SH3P7; PP5423 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	YVRVVTEKSPTDWAL	ubiquitination	[1]
164	PVGSVYQKTNAVSEI	ubiquitination	[1, 2]
176	SEIKRVGKDSFWAKA	acetylation	[3]
288	LRSPFLQKQLTQPET	acetylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. 

Sequence Annotation

 DOMAIN 4 133 ADF-H.
 DOMAIN 371 430 SH3.
 MOD_RES 176 176 N6-acetyllysine.
 MOD_RES 232 232 Phosphoserine.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 270 270 Phosphothreonine (By similarity).
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 288 288 N6-acetyllysine.
 MOD_RES 291 291 Phosphothreonine (By similarity).
 MOD_RES 334 334 Phosphotyrosine (By similarity).
 MOD_RES 344 344 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Actin-binding; Adaptive immunity; Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Golgi apparatus; Immunity; Membrane; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; ISS:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0051015; F:actin filament binding; ISS:UniProtKB.
 GO:0008047; F:enzyme activator activity; TAS:ProtInc.
 GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
 GO:0071800; P:podosome assembly; ISS:UniProtKB.
 GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR001452; SH3_domain. 

Pfam

 PF00241; Cofilin_ADF
 PF00018; SH3_1 

SMART

 SM00102; ADF
 SM00326; SH3 

PROSITE

 PS51263; ADF_H
 PS50002; SH3 

PRINTS