CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038650
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Pik3c2b 
Protein Synonyms/Alias
  
Gene Name
 Pik3c2b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
240AITRLNLKSTYDSEIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1632 AA 
Protein Sequence
MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHHKEESRAK QNTEPSLISW 60
DEPALDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSISPPE GLPNSTSQDP QPGPDPWPKG 120
SLSGDYLYIF DGSEGRCSLS PGSGDTDGSC KKLSPPPLPP RVSIWDAPPL PPRKGSPSPS 180
KISQPNDINS FSSAEQPPDK LLVAQDPEEG ELPDGRGQGH TLGSVDYDGI NDAITRLNLK 240
STYDSEISSD ATRGWKEGRG PLDFNKDTSG KPVARSKTMP PQVPPRTYTS RYANRKNATP 300
GNNRRISAAP VGSRPHTVAN GHELFEVSEE RDEEVAAFCH MLDILRTGSD IQDYSLTGCV 360
WSTVTPSPEH LGDEVNLKVT VLCDSLREPL TFTCNCSSTV DLLIHQTLCY THDELREVDV 420
GDFVLKPCGL EEFLQNKHAL GSHEYIQYCR KFDISIRLQL MEQKAIRSDL ARTVNDDQSP 480
STLNYLIHLQ ERPVKQTISR QALSLLFDTY HNEVDAFLLA DGDFPLKADR VVQSVKAICN 540
ALAAVETPEI TSALNQLPPC PSRMQPKIQK DPSVLSVREN REKVVEALTA AILDLVELYC 600
STFNADFQTA VPGSRKHDLV QEACHFPGAL AFTVYGTHRI PIIWATSYED FYLSCSLSHG 660
GKELCSPLQT RRAHFSKYLF HLIIWDQQIC FPVQVNRLPR ETLLCATLYA LPVPPPGGSS 720
EANKQKRVPE ALGWVTTPLF NFRQVLTCGR KLLGLWPATQ ENSGARWSAP NFHQPDSVIL 780
QIDFPSSAFD IKFTSPPGDK FSPRYEFGSL REEDQRKLKD ITQKESLYWL TDADKKQLWE 840
KRYYCHTEVS SLPLVLASAP SWEWACLPDI YALLQQWTHM NHQDALGLLH ATFPDQEVRR 900
MAVQWIGSLS DAELLDYLPQ LVQALKYECY LDSPLVRFLL KRAISDLRVT HYFFWLLKDS 960
LKDSQFSIRY QYLLAALLCC CGKGLREEFN RQCWLVNTLA KLAQQVREAT PSARQGILRV 1020
GLEEVKQFFA LNGSCRLPLS PSLLVKGIVP RDCSYFNSNA VPLKLAFQNV DPLGENIRVI 1080
FKCGDDLRQD MLTLQMIRIM SKIWVQEGLD MRMVIFRCFS TGRGKGMVEM IPNAETLRKI 1140
QVEHGVTGSF KDRPLADWLQ KHNPGEDEYE KAVENFIYSC AGCCVATYIL GICDRHNDNI 1200
MLKTTGHMFH IDFGRFLGHA QMFGNIKRDR APFVFTSDMA YVINGGDKPS SRFHDFVDLC 1260
CQAYNLIRKH THLFLNLLGL MLSCGIPELS DLEDLKYVYD ALRPQDTEAN ATTYFTRLIE 1320
SSLGSVATKL NFFIHNLAQM KFTGSDDRLT LSFAPRTHTL KSSGRIRDVF LCRHEKIFHP 1380
SKGYVYVVKV MRENAHEATY IQRTFEEFQE LHNKLRLLFP SSFLPSFPSR FVIGRSRGEA 1440
VAERRKEELN GYIWHLIHAA PEVAECDLVY TFFHPLPRDE KASGPSPAPK SSDGTWARPV 1500
GKVGGEVKLS ISYKNNKLFI MVMHIRGLQP LQDGNDPDPY VKIYLLPDPQ KTTKRKTKVA 1560
RKTCNPTYNE MLVYDGIPKG DLQQRELQLS VLSEQGFWEN LLLGEVHIRL RELDLAQEKT 1620
GWFGLGSRGH GT 1632 
Gene Ontology
 GO:0030139; C:endocytic vesicle; IDA:MGI.
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:RefGenome.
 GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0001727; F:lipid kinase activity; IDA:MGI.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
 GO:0043491; P:protein kinase B signaling cascade; IDA:MGI. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011009; Kinase-like_dom.
 IPR001683; Phox.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR002420; PI3K_C2_dom.
 IPR000341; PI3K_Ras-bd_dom.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00168; C2
 PF00454; PI3_PI4_kinase
 PF00792; PI3K_C2
 PF00794; PI3K_rbd
 PF00613; PI3Ka
 PF00787; PX 
SMART
 SM00239; C2
 SM00142; PI3K_C2
 SM00144; PI3K_rbd
 SM00145; PI3Ka
 SM00146; PI3Kc
 SM00312; PX 
PROSITE
 PS50004; C2
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51547; PI3K_C2
 PS51546; PI3K_RBD
 PS51545; PIK_HELICAL
 PS50195; PX 
PRINTS