CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025617
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NUMA1 variant protein 
Protein Synonyms/Alias
  
Gene Name
 NUMA1 variant protein 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60EEGQQILKQPVSERLubiquitination[1, 2]
253NRKLLTEKDAQIAMMubiquitination[1]
273RLALLNEKQAASPLEubiquitination[1]
332ENGDLSFKLREFASHubiquitination[1, 2]
364ATQEWLEKQAQLEKEubiquitination[1, 2]
370EKQAQLEKELSAALQubiquitination[2]
392KNEILQGKLSQLEEHubiquitination[1, 2]
455ERGQQEAKLLAERGHubiquitination[1]
567EQLSSSLKQKEQQLKubiquitination[1]
610RERDAALKQLEALEKubiquitination[1, 2]
622LEKEKAAKLEILQQQubiquitination[1, 2]
861ELQEAKEKVAGIESHubiquitination[2]
897ALQQVQEKEVRAQKLubiquitination[1, 2]
914DLSTLQEKMAATSKEubiquitination[1, 2]
1127RTEPTGPKLEALRAEubiquitination[1]
1137ALRAEVSKLEQQCQKubiquitination[1]
1336EELGQELKAWQEKFFubiquitination[2]
1341ELKAWQEKFFQKEQAubiquitination[1, 2]
1436AQQLRAEKASYAEQLubiquitination[1, 2]
1481ELDQAREKYVQELAAubiquitination[1, 2]
1517ELEVMTAKYEGAKVKubiquitination[1, 2]
1524KYEGAKVKVLEERQRubiquitination[1]
1705QQLRDLGKFQVATDAubiquitination[1, 2]
1714QVATDALKSREPQAKubiquitination[1, 2]
1772ISQRLPPKVESLESLubiquitination[1, 2]
1827IINITMTKKLDVEEPubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2121 AA 
Protein Sequence
LSGITKMTLH ATRGAALLSW VNSLHVADPV EAVLQLQDCS IFIKIIDRIH GTEEGQQILK 60
QPVSERLDFV CSFLQKNRKH PSSPECLVSA QKVLEGSELE LAKMTMLLLY HSTMSSKSPR 120
DWEQFEYKIQ AELAVILKFV LDHEDGLNLN EDLENFLQKA PVPSTCSSTF PEELSPPSHQ 180
AKREIRFLEL QKVASSSSGN NFLSGSPASP MGDILQTPQF QMRRLKKQLA DERSNRDELE 240
LELAENRKLL TEKDAQIAMM QQRIDRLALL NEKQAASPLE PKELEELRDK NESLTMRLHE 300
TLKQCQDLKT EKSQMDRKIN QLSEENGDLS FKLREFASHL QQLQDALNEL TEEHSKATQE 360
WLEKQAQLEK ELSAALQDKK CLEEKNEILQ GKLSQLEEHL SQLQDNPPQE KGEVLGDVLQ 420
LETLKQEAAT LAANNTQLQA RVEMLETERG QQEAKLLAER GHFEEEKQQL SSLITDLQSS 480
ISNLSQAKEE LEQASQAHGA RLTAQVASLT SELTTLNATI QQQDQELAGL KQQAKEKQAQ 540
LAQTLQQQEQ ASQGLRHQVE QLSSSLKQKE QQLKEVAEKQ EATRQDHAQQ LATAAEEREA 600
SLRERDAALK QLEALEKEKA AKLEILQQQL QVANEARDSA QTSVTQAQRE KAELSRKVEE 660
LQACVETARQ EQHEAQAQVA ELELQLRSEQ QKATEKERVA QEKDQLQEQL QALKESLKVT 720
KGSLEEEKRR AADALEEQQR CISELKAETR SLVEQHKRER KELEEERAGR KGLEARLQQL 780
GEAHQAETEV LRRELAEAMA AQHTAESECE QLVKEVAAWR ERYEDSQQEE AQYGAMFQEQ 840
LMTLKEECEK ARQELQEAKE KVAGIESHSE LQISRQQNEL AELHANLARA LQQVQEKEVR 900
AQKLADDLST LQEKMAATSK EVARLETLVR KAGEQQETAS RELVKEPARA GDRQPEWLEE 960
QQGRQFCSTQ AALQAMEREA EQMGNELERL RAALMESQGQ QQEERGQQER EVARLTQERG 1020
RAQADLALEK AARAELEMRL QNALNEQRVE FATLQEALAH ALTEKEGKDQ ELAKLRGLEA 1080
AQIKELEELR QTVKQLKEQL AKKEKEHASG SGAQSEAAGR TEPTGPKLEA LRAEVSKLEQ 1140
QCQKQQEQAD SLERSLEAER ASRAERDSAL ETLQGQLEEK AQELGHSQSA LASAQRELAA 1200
FRTKVQDHSK AEDEWKAQVA RGRQEAERKN SLISSLEEEV SILNRQVLEK EGESKELKRL 1260
VMAESEKSQK LEERLRLLQA ETASNSARAA ERSSALREEV QSLREEAEKQ RVASENLRQE 1320
LTSQAERAEE LGQELKAWQE KFFQKEQALS TLQLEHTSTQ ALVSELLPAK HLCQQLQAEQ 1380
AAAEKRHREE LEQSKQAAGG LRAELLRAQR ELGELIPLRQ KVAEQERTAQ QLRAEKASYA 1440
EQLSMLKKAH GLLAEENRGL GERANLGRQF LEVELDQARE KYVQELAAVR ADAETRLAEV 1500
QREAQSTARE LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEQLEVFQ REQTKQVEEL 1560
SKKLADSDQA SKVQQQKLKA VQAQGGESQQ EAQRLQAQLN ELQAQLSQKE QAAEHYKLQM 1620
EKAKTHYDAK KQQNQELQEQ LRSLEQLQKE NKELRAEAER LGHELQQAGL KTKEAEQTCR 1680
HLTAQVRSLE AQVAHADQQL RDLGKFQVAT DALKSREPQA KPQLDLSIDS LDLSCEEGTP 1740
LSITSKLPRT QPDGTSVPGE PASPISQRLP PKVESLESLY FTPIPARSQA PLESSLDSLG 1800
DVFLDSGRKT RSARRRTTQI INITMTKKLD VEEPDSANSS FYSTRSAPAS QASLRATSST 1860
QSLARLGSPD YGNSALLSLP GYRPTTRSSA RRSQAGVSSG APPGRNSFYM GTCQDEPEQL 1920
DDWNRIAELQ QRNRVCPPHL KTCYPLESRP SLSLGTITDE EMKTGDPQET LRRASMQPIQ 1980
IAEGTGITTR QQRKRVSLEP HQGPGTPESK KATSCFPRPM TPRDRHEGRK QSTTEAQKKA 2040
APASTKQADR RQSMAFSILN TPKKLGNSLL RRGASKKALS KASPNTRSGT RRSPRIATTT 2100
ASAATAAAIG ATPRAKGKAK H 2121 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000132; P:establishment of mitotic spindle orientation; IEA:Compara.
 GO:0060487; P:lung epithelial cell differentiation; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS