CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011800
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingolipid long chain base-responsive protein LSP1 
Protein Synonyms/Alias
  
Gene Name
 LSP1 
Gene Synonyms/Alias
 YPL004C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
63RKLSQLVKTEKGVLRacetylation[1]
148PSRDRKEKITDEIAHacetylation[1]
157TDEIAHLKYKDPQSTacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. 
Sequence Annotation
 MOD_RES 233 233 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MHRTYSLRNQ RAPTAAELQA PPPPPSSTKS KFFGKASIAS SFRKNAAGNF GPELARKLSQ 60
LVKTEKGVLR AMEVVASERR EAAKQLSLWG ADNDDDVSDV TDKLGVLIYE LGELQDQFID 120
KYDQYRVTLK SIRNIEASVQ PSRDRKEKIT DEIAHLKYKD PQSTKIPVLE QELVRAEAES 180
LVAEAQLSNI TREKLKAAYS YMFDSLRELS EKFALIAGYG KALLELLDDS PVTPGEARPA 240
YDGYEASRQI IMDAESALES WTLDMAAVKP TLSFHQTVDD VYEDEDGEEE EEPEIQNGDI 300
PGQVVEEEEV EWTTEVPVDD EAHEADHHVS QNGHTSGSEN I 341 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0032126; C:eisosome; IDA:SGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0008289; F:lipid binding; IDA:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0006469; P:negative regulation of protein kinase activity; IMP:SGD.
 GO:0009408; P:response to heat; IMP:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS