CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Centrosomal protein of 192 kDa 
Protein Synonyms/Alias
  
Gene Name
 CEP192 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
117RLSNALSKQSALQMEubiquitination[1]
170LQSWMNNKEPKIVVLubiquitination[1]
181IVVLDAGKHFEDKTLacetylation[2, 3]
181IVVLDAGKHFEDKTLubiquitination[1, 3]
186AGKHFEDKTLKSDLSubiquitination[1]
189HFEDKTLKSDLSHTSubiquitination[1]
336SGTWGTEKEIENLKGubiquitination[1]
355LNSECASKDVLVKTLubiquitination[3]
360ASKDVLVKTLRAIDVubiquitination[1]
368TLRAIDVKLNSDNFHubiquitination[1]
391FDLTDPVKQGAECPHubiquitination[1]
571RSTSDLDKDDASYLRubiquitination[1]
602LGGGNNVKRPSFGYFubiquitination[1, 3]
615YFIRSPEKREPIALIubiquitination[1]
687TLTADKGKTEDTFFMubiquitination[1]
697DTFFMSNKPQRYKDKubiquitination[1]
704KPQRYKDKLPDSGDSubiquitination[1]
772FLPNDLEKSNGSNALubiquitination[1]
783SNALDMEKYLKKTEVubiquitination[1]
815TWDLSLPKEQTTQDIubiquitination[1]
880NSAVVDVKTCSIDNKubiquitination[1]
896QDVGNDEKATSISTPubiquitination[1]
1138KPDFRWSKDPSSKSGubiquitination[1]
1172IRLALLGKSGLSCQVubiquitination[1]
1661QTMHFLAKVASSRKQubiquitination[1]
1786LGRTQLQKLALRNNSubiquitination[1]
1859MLARLEIKQLGNRSQubiquitination[1]
1891LILEGVKKLSDSYMVubiquitination[1]
1926GSRAAFVKAVGFKDSubiquitination[1]
1942KKVLLDPKVLRIFPDubiquitination[1]
1954FPDKFVLKERTQENVubiquitination[1]
1975SDRGINNKTATELSTubiquitination[1]
2003YRRALLHKPEMIKQIubiquitination[1]
2078EFLQPSSKASLESTSubiquitination[1]
2317SLAPPYVKGVDESGDubiquitination[1]
2415IKIDHLVKPRRQAVSubiquitination[1]
2536LIGEALGKN******ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2537 AA 
Protein Sequence
MEDFRGIAEE SFPSFLTNSL FGNSGILENV TLSSNLGLPV AVSTLARDRS STDNRYPDIQ 60
ASYLVEGRFS VPSGSSPGSQ SDAEPRERLQ LSFQDDDSIS RKKSYVESQR LSNALSKQSA 120
LQMETAGPEE EPAGATESLQ GQDLFNRASP LEQAQDSPID FHLQSWMNNK EPKIVVLDAG 180
KHFEDKTLKS DLSHTSLLEN EKLILPTSLE DSSDDDIDDE MFYDDHLEAY FEQLAIPGMI 240
YEDLEGPEPP EKGFKLPTNG LRQANENGSL NCKFQSENNS SLISLDSHSS ETTHKESEES 300
QVICLPGTSN SIGTGDSRRY TDGMLPFSSG TWGTEKEIEN LKGIVPDLNS ECASKDVLVK 360
TLRAIDVKLN SDNFHDANAN RGGFDLTDPV KQGAECPHQN KTVLHMDGCL DTETPTVSIQ 420
ENVDVASLKP ISDSGINFTD AIWSPTCERR TCECHESIEK NKDKTDLPQS VVYQNEEGRW 480
VTDLAYYTSF NSKQNLNVSL SDEMNEDFRS GSEAFDLIAQ DEEEFNKEHQ FIQEENIDAH 540
NTSVALGDTS WGATINYSLL RKSRSTSDLD KDDASYLRLS LGEFFAQRSE ALGCLGGGNN 600
VKRPSFGYFI RSPEKREPIA LIRKSDVSRG NLEKEMAHLN HDLYSGDLNE QSQAQLSEGS 660
ITLQVEAVES TSQVDENDVT LTADKGKTED TFFMSNKPQR YKDKLPDSGD SMLRISTIAS 720
AIAEASVNTD PSQLAAMIKA LSNKTRDKTF QEDEKQKDYS HVRHFLPNDL EKSNGSNALD 780
MEKYLKKTEV SRYESALENF SRASMSDTWD LSLPKEQTTQ DIHPVDLSAT SVSVRAPEEN 840
TAAIVYVENG ESENQESFRT INSSNSVTNR ENNSAVVDVK TCSIDNKLQD VGNDEKATSI 900
STPSDSYSSV RNPRITSLCL LKDCEEIRDN RENQRQNECV SEISNSEKHV TFENHRIVSP 960
KNSDLKNTSP EHGGRGSEDE QESFRPSTSP LSHSSPSEIS GTSSSGCALE SFGSAAQQQQ 1020
PPCEQELSPL VCSPAGVSRL TYVSEPESSY PTTATDDALE DRKSDITSEL STTIIQGSPA 1080
ALEERAMEKL REKVPFQNRG KGTLSSIIQN NSDTRKATET TSLSSKPEYV KPDFRWSKDP 1140
SSKSGNLLET SEVGWTSNPE ELDPIRLALL GKSGLSCQVG SATSHPVSCQ EPIDEDQRIS 1200
PKDKSTAGRE FSGQVSHQTT SENQCTPIPS STVHSSVADM QNMPAAVHAL LTQPSLSAAP 1260
FAQRYLGTLP STGSTTLPQC HAGNATVCGF SGGLPYPAVA GEPVQNSVAV GICLGSNIGS 1320
GWMGTSSLCN PYSNTLNQNL LSTTKPFPVP SVGTNCGIEP WDSGVTSGLG SVRVPEELKL 1380
PHACCVGIAS QTLLSVLNPT DRWLQVSIGV LSISVNGEKV DLSTYRCLVF KNKAIIRPHA 1440
TEEIKVLFIP SSPGVFRCTF SVASWPCSTD AETIVQAEAL ASTVTLTAIA ESPVIEVETE 1500
KKDVLDFGDL TYGGWKALPL KLINRTHATV PIRLIINANA VAWRCFTFSK ESVRAPVEVA 1560
PCADVVTRLA GPSVVNHMMP ASYDGQDPEF LMIWVLFHSP KKQISSSDIL DSAEEFSAKV 1620
DIEVDSPNPT PVLRSVSLRA RAGIARIHAP RDLQTMHFLA KVASSRKQHL PLKNAGNIEV 1680
YLDIKVPEQG SHFSVDPKNL LLKPGEEHEV IVSFTPKDPE ACEERILKIF VQPFGPQYEV 1740
VLKGEVISSG SKPLSPGPCL DIPSILSNKQ FLAWGGVPLG RTQLQKLALR NNSASTTQHL 1800
RLLIRGQDQD CFQLQNTFGS EQRLTSNCEI RIHPKEDIFI SVLFAPTRLS CMLARLEIKQ 1860
LGNRSQPGIK FTIPLSGYGG TSNLILEGVK KLSDSYMVTV NGLVPGKESK IVFSVRNTGS 1920
RAAFVKAVGF KDSQKKVLLD PKVLRIFPDK FVLKERTQEN VTLIYNPSDR GINNKTATEL 1980
STVYLFGGDE ISRQQYRRAL LHKPEMIKQI LPEHSVLQNI NFVEAFQDEL LVTEVYDLPQ 2040
RPNDVQLFYG SMCKIILSVI GEFRDCISSR EFLQPSSKAS LESTSDLGAS GKHGGNVSLD 2100
VLPVKGPQGS PLLSRAARPP LDQLASEEPW TVLPEHLILV APSPCDMAKT GRFQIVNNSV 2160
RLLRFELCWP AHCLTVTPQH GCVAPESKLQ ILVSPNSSLS TKQSMFPWSG LIYIHCDDGQ 2220
KKIVKVQIRE DLTQVELLTR LTSKPFGILS PVSEPSVSHL VKPMTKPPST KVEIRNKSIT 2280
FPTTEPGETS ESCLELENHG TTDVKWHLSS LAPPYVKGVD ESGDVFRATY AAFRCSPISG 2340
LLESHGIQKV SITFLPRGRG DYAQFWDVEC HPLKEPHMKH TLRFQLSGQS IEAENEPENA 2400
CLSTDSLIKI DHLVKPRRQA VSEASARIPE QLDVTARGVY APEDVYRFRP TSVGESRTLK 2460
VNLRNNSFIT HSLKFLSPRE PFYVKHSKYS LRAQHYINMP VQFKPKSAGK FEALLVIQTD 2520
EGKSIAIRLI GEALGKN 2537 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000242; C:pericentriolar material; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS