| Tag | Content |
|---|
| CPLM ID | CPLM-008109 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glycine dehydrogenase [decarboxylating], mitochondrial |
Protein Synonyms/Alias | Glycine cleavage system P protein; Glycine decarboxylase; Glycine decarboxylase complex subunit P |
Gene Name | GCV2 |
Gene Synonyms/Alias | GSD2; YMR189W; YM9646.01 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 58 | RIFNPDLKNIDRPLD | acetylation | [1] | | 80 | GPSPSDVKKMLKTMG | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. |
Sequence Annotation | MOD_RES 773 773 N6-(pyridoxal phosphate)lysine (By |
Keyword | Complete proteome; Mitochondrion; Oxidoreductase; Pyridoxal phosphate; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1034 AA |
Protein Sequence | MLRTRVTALL CRATVRSSTN YVSLARTRSF HSQSILLKTA ATDITSTQYS RIFNPDLKNI 60
DRPLDTFARR HLGPSPSDVK KMLKTMGYSD LNAFIEELVP PNILKRRPLK LEAPSKGFCE 120
QEMLQHLEKI ANKNHYKVKN FIGKGYYGTI LPPVIQRNLL ESPEWYTSYT PYQPEISQGR 180
LEALLNFQTV VSDLTGLPVA NASLLDEGTA AGEAMLLSFN ISRKKKLKYV IDKKLHQQTK 240
SVLHTRAKPF NIEIIEVDCS DIKKAVDVLK NPDVSGCLVQ YPATDGSILP PDSMKQLSDA 300
LHSHKSLLSV ASDLMALTLL KPPAHYGADI VLGSSQRFGV PMGYGGPHAA FFAVIDKLNR 360
KIPGRIVGIS KDRLGKTALR LALQTREQHI KRDKATSNIC TAQALLANVA SSYCVYHGPK 420
GLQNISRRIF SLTSILANAI ENDSCPHELI NKTWFDTLTI KLGNGISSEQ LLDKALKEFN 480
INLFAVDTTT ISLALDETTT KADVENLLKV FDIENSSQFL SEDYSNSFPR EFQRTDEILR 540
NEVFHMHHSE TAMLRYLHRL QSRDLSLANS MIPLGSCTMK LNSTVEMMPI TWPQFSNIHP 600
FQPSNQVQGY KELITSLEKD LCSITGFDGI SLQPNSGAQG EYTGLRVIRS YLESKGENHR 660
NVCLIPVSAH GTNPASAAMA GLKVVPVNCL QDGSLDLVDL KNKAEQHSKE LAAVMITYPS 720
TYGLFEPGIQ HAIDIVHSFG GQVYLDGANM NAQVGLTSPG DLGADVCHLN LHKTFSIPHG 780
GGGPAGAPIC VKSHLIPHLP KHDVVDMITG IGGSKSIDSV SSAPYGNALV LPISYAYIKM 840
MGNEGLPFSS VIAMLNSNYM MTRLKDHYKI LFVNEMSTLK HCAHEFIVDL REYKAKGVEA 900
IDVAKRLQDY GFHAPTLAFP VPGTLMIEPT ESENLEELDR FCDAMISIKE EINALVAGQP 960
KGQILKNAPH SLEDLITSSN WDTRGYTREE AAYPLPFLRY NKFWPTVARL DDTYGDMNLI 1020
CTCPSVEEIA NETE 1034 |
Gene Ontology | GO:0005960; C:glycine cleavage complex; ISS:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IDA:SGD. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEP:SGD. GO:0006730; P:one-carbon metabolic process; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |