CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 G patch domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 GPATCH4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18EVKSRGMKFAEEQLLubiquitination[1]
26FAEEQLLKHGWTQGKacetylation[2]
26FAEEQLLKHGWTQGKubiquitination[1, 3]
33KHGWTQGKGLGRKENubiquitination[1]
38QGKGLGRKENGITQAubiquitination[1]
173ARLGITMKAKLARLEubiquitination[1]
175LGITMKAKLARLEAQubiquitination[1]
191QAFLARLKGQDPGAPubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MFPRSGPSND EVKSRGMKFA EEQLLKHGWT QGKGLGRKEN GITQALRVTL KQDTHGVGHD 60
PAKEFTNHWW NELFNKTAAN LVVETGQDGV QIRSLSKETT RYNHPKPNLL YQKFVKMATL 120
TSGGEKPNKD LESCSDDDNQ GSKSPKILTD EMLLQACEGR TAHKAARLGI TMKAKLARLE 180
AQEQAFLARL KGQDPGAPQL QSESKPPKKK KKKRRQKEEE EATASERNDA DEKHPEHAEQ 240
NIRKSKKKKR RHQEGKVSDE REGTTKGNEK EDAAGTSGLG ELNSREQTNQ SLRKGKKKKR 300
WHHEEEKMGV LEEGGKGKEA AGSVRTEEVE SRAYADPCSR RKKRQQQEEE DLNLEDRGEE 360
TFRWWNQGSR EQSMQ 375 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR000467; G_patch_dom. 
Pfam
 PF01585; G-patch 
SMART
 SM00443; G_patch 
PROSITE
 PS50174; G_PATCH 
PRINTS