CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009801
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trigger factor 
Protein Synonyms/Alias
 TF; PPIase 
Gene Name
 tig 
Gene Synonyms/Alias
 STM0447 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
368KADEERVKGLIEEMAacetylation[1]
392IEFYSKNKELMDNMRacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). 
Sequence Annotation
 DOMAIN 161 246 PPIase FKBP-type.  
Keyword
 Cell cycle; Cell division; Chaperone; Complete proteome; Cytoplasm; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 432 AA 
Protein Sequence
MQVSVETTQG LGRRVTITIA ADSIETAVKS ELVNVAKKVR IDGFRKGKVP MNIVAQRYGA 60
SVRQDVLGDL MSRNFVDAII KEKINPAGAP NYVPGEYKVG EDFTYSVEFE VYPEVELTGL 120
ESIEVEKPVV EVTDADVDVM LDTLRKQQAT WKEKDGAADA EDRVTIDFTG SVDGEEFEGG 180
KATDFVLAMG QGRMIPGFED GVKGHKAGEE FTIDVTFPEE YHAENLKGKA AKFVINLKKV 240
EERELPELTE EFIKRFGVED GSVAGLRAEV RKNMERELKG AVRNRVKSQA IEGLVKANDI 300
DVPSALIDSE IDVLRRQAAQ RFGGNEKQAL ELPRELFEEQ AKRRVVVGLL LGEVIRTNEL 360
KADEERVKGL IEEMASAYED PKEVIEFYSK NKELMDNMRN VALEEQAVEA VLAKAKVSEK 420
ATSFNELMNQ QA 432 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:HAMAP.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0015031; P:protein transport; IEA:HAMAP. 
Interpro
 IPR001179; PPIase_FKBP_dom.
 IPR005215; Trig_fac.
 IPR008880; Trigger_fac_C.
 IPR008881; Trigger_fac_ribosome-bd_bac.
 IPR027304; Trigger_fact/SurA_dom. 
Pfam
 PF00254; FKBP_C
 PF05698; Trigger_C
 PF05697; Trigger_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS