UniProt Accession

 MOC2A_HUMAN; O96033 

Genbank Protein ID

 AF091871; AF117815 

Genbank Nucleotide ID

 AAD14598.1; AAD13296.1 

Protein Name

 Molybdopterin synthase sulfur carrier subunit 

Protein Synonyms/Alias

 MOCO1-A; Molybdenum cofactor synthesis protein 2 small subunit; Molybdenum cofactor synthesis protein 2A; MOCS2A; Molybdopterin-synthase small subunit; Sulfur carrier protein MOCS2A 

Gene Name

 MOCS2 

Gene Synonyms/Alias

 MOCO1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	ISVPQEIKALQLWKE	ubiquitination	[1, 2]
39	IKALQLWKEIETRHP	ubiquitination	[3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. 

Sequence Annotation

 MOD_RES 88 88 1-thioglycine; alternate.
 MOD_RES 88 88 Glycyl adenylate; alternate.  

Keyword

 Complete proteome; Cytoplasm; Disease mutation; Molybdenum cofactor biosynthesis; Nucleotide-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0019008; C:molybdopterin synthase complex; IPI:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IDA:UniProtKB.
 GO:0006767; P:water-soluble vitamin metabolic process; TAS:Reactome. 

Interpro

 IPR012675; Beta-grasp_dom.
 IPR010034; Mopterin_su_1.
 IPR016155; Mopterin_synth/thiamin_S_b.
 IPR003749; ThiS/MoaD. 

Pfam

 PF02597; ThiS 

SMART

  

PROSITE

  

PRINTS