CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Annexin 
Protein Synonyms/Alias
  
Gene Name
 Anxa4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28QTLRKAMKGLGTDEDubiquitination[1]
57QEIRSAYKSTIGRDLacetylation[2]
162ELYEAGEKRWGTDEVubiquitination[1]
170RWGTDEVKFLSILCSacetylation[2]
191LHVFDEYKRISQKDIacetylation[2]
196EYKRISQKDIEQSIKacetylation[2]
203KDIEQSIKSETSGSFacetylation[2]
219DALLAIVKCMRSKPSacetylation[2]
224IVKCMRSKPSYFAERacetylation[2]
224IVKCMRSKPSYFAERubiquitination[1]
237ERLYKSMKGLGTDDNacetylation[2, 3]
237ERLYKSMKGLGTDDNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
  
Sequence Annotation
  
Keyword
 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 254 AA 
Protein Sequence
MEAKGGTVKA ASGFNATEDA QTLRKAMKGL GTDEDAIIGI LAYRNTAQRQ EIRSAYKSTI 60
GRDLIEDLKS ELSSNFEQGA GTDEGCLIEI LASRTPEEIR RINQTYQQQY GRSLEEDICS 120
DTSFMFQRVL VSLSAAGRDE GNYLDDALMK QDAQELYEAG EKRWGTDEVK FLSILCSRNR 180
NHLLHVFDEY KRISQKDIEQ SIKSETSGSF EDALLAIVKC MRSKPSYFAE RLYKSMKGLG 240
TDDNTLIRVM VSRA 254 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0001822; P:kidney development; ISA:MGI. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002391; AnnexinIV. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.