CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbonic anhydrase 2 
Protein Synonyms/Alias
 Carbonate dehydratase II; Carbonic anhydrase II; CA-II 
Gene Name
 Ca2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
9SHHWGYSKSNGPENWacetylation[1]
18NGPENWHKEFPIANGacetylation[1]
53PLLICYDKVASKSIVacetylation[1]
80SQDFAVLKEGPLSGSacetylation[1]
112SEHTVNKKKYAAELHacetylation[1]
113EHTVNKKKYAAELHLacetylation[1]
126HLVHWNTKYGDFGKAacetylation[1]
132TKYGDFGKAVQHPDGacetylation[1]
158PASQGLQKITEALHSacetylation[1]
167TEALHSIKTKGKRAAacetylation[1]
227EQMSHFRKLNFNSEGacetylation[1]
256PLKNRKIKASFK***acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. 
Sequence Annotation
 REGION 198 199 Substrate binding (By similarity).
 ACT_SITE 64 64 Proton acceptor (By similarity).
 ACT_SITE 67 67 By similarity.
 ACT_SITE 127 127 By similarity.
 METAL 94 94 Zinc; catalytic.
 METAL 96 96 Zinc; catalytic.
 METAL 119 119 Zinc; catalytic.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 87 87 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 260 AA 
Protein Sequence
MSHHWGYSKS NGPENWHKEF PIANGDRQSP VDIDTGTAQH DPSLQPLLIC YDKVASKSIV 60
NNGHSFNVEF DDSQDFAVLK EGPLSGSYRL IQFHFHWGSS DGQGSEHTVN KKKYAAELHL 120
VHWNTKYGDF GKAVQHPDGL AVLGIFLKIG PASQGLQKIT EALHSIKTKG KRAAFANFDP 180
CSLLPGNLDY WTYPGSLTTP PLLECVTWIV LKEPITVSSE QMSHFRKLNF NSEGEAEELM 240
VDNWRPAQPL KNRKIKASFK 260 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:RGD.
 GO:0030424; C:axon; IDA:RGD.
 GO:0016323; C:basolateral plasma membrane; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0005902; C:microvillus; IDA:RGD.
 GO:0004089; F:carbonate dehydratase activity; IDA:RGD.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0015670; P:carbon dioxide transport; IEA:Compara.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0002009; P:morphogenesis of an epithelium; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEP:RGD.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
 GO:0030316; P:osteoclast differentiation; TAS:RGD.
 GO:0045780; P:positive regulation of bone resorption; IMP:RGD.
 GO:0032849; P:positive regulation of cellular pH reduction; IMP:RGD.
 GO:0045672; P:positive regulation of osteoclast differentiation; IMP:RGD.
 GO:0030641; P:regulation of cellular pH; TAS:RGD.
 GO:0043627; P:response to estrogen stimulus; IEP:RGD.
 GO:0009268; P:response to pH; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0046903; P:secretion; IEA:Compara. 
Interpro
 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018440; Carbonic_anhydrase_CA2. 
Pfam
 PF00194; Carb_anhydrase 
SMART
 SM01057; Carb_anhydrase 
PROSITE
 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 
PRINTS