CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 KxDL motif-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Kxd1 
Gene Synonyms/Alias
 2810422J05Rik 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
110ANMQIFVKTLTGKTIacetylation[1, 2, 3]
110ANMQIFVKTLTGKTIsuccinylation[3]
110ANMQIFVKTLTGKTIubiquitination[4]
115FVKTLTGKTITLEVEacetylation[2, 5]
115FVKTLTGKTITLEVEubiquitination[4]
131SDTIENVKAKIQDKEacetylation[2, 3]
131SDTIENVKAKIQDKEsuccinylation[3]
131SDTIENVKAKIQDKEubiquitination[4]
152QRLIFAGKQLEDGRTacetylation[2, 3, 5, 6]
152QRLIFAGKQLEDGRTsuccinylation[3]
152QRLIFAGKQLEDGRTubiquitination[4]
167LSDYNIQKESTLHLVacetylation[2, 5]
167LSDYNIQKESTLHLVubiquitination[4]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 193 AA 
Protein Sequence
MDTPDSASRV FCGRFLSMVN TDDVNAIILA QKNMLDRFEK TNEMLLNFNN LSSVRLQQMS 60
ERFMHHTRTL VDMKRDLDSI FRRIRTLKGK LARQHPEAFS PDANMQIFVK TLTGKTITLE 120
VEPSDTIENV KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL SDYNIQKEST LHLVLRLRGG 180
IIEPSLRQLA QKY 193 
Gene Ontology
  
Interpro
 IPR000626; Ubiquitin.
 IPR019954; Ubiquitin_CS.
 IPR019956; Ubiquitin_subgr.
 IPR019955; Ubiquitin_supergroup.
 IPR019371; Uncharacterised_KxDL. 
Pfam
 PF10241; KxDL
 PF00240; ubiquitin 
SMART
 SM00213; UBQ 
PROSITE
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS
 PR00348; UBIQUITIN.