CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta 
Protein Synonyms/Alias
 PP2A subunit B isoform PR48; Protein phosphatase 2A 48 kDa regulatory subunit 
Gene Name
 PPP2R3B 
Gene Synonyms/Alias
 PPP2R3L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12KVLQPVLKMKVDELFubiquitination[1]
113TRVVQTRKEEPLPPAubiquitination[1]
147NVDAVISKIESTFARubiquitination[1]
170DDMGLVAKACGCPLYubiquitination[1]
179CGCPLYWKGPLFYGAubiquitination[1]
350NDHALSTKMIDRIFSubiquitination[1]
452VKPRTEGKITLQDLKubiquitination[1]
459KITLQDLKRCKLANVubiquitination[1]
483KYLDHEQKEQISLLRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 
Sequence Annotation
 DOMAIN 388 423 EF-hand.  
Keyword
 3D-structure; Alternative splicing; Calcium; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 575 AA 
Protein Sequence
MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG DGEQPGAWPT 60
APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT RRSAGTRVVQ TRKEEPLPPA 120
TSQSIPTFYF PRGRPQDSVN VDAVISKIES TFARFPHERA TMDDMGLVAK ACGCPLYWKG 180
PLFYGAGGER TGSVSVHKFV AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD 240
VVNTHPGLSF LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE 300
EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK MIDRIFSGAV 360
TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM DLDGDGALSM FELEYFYEEQ 420
CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE GKITLQDLKR CKLANVFFDT FFNIEKYLDH 480
EQKEQISLLR DGDSGGPELS DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA 540
LRSPLAQRPF FEAPSPLGAV DLYEYACGDE DLEPL 575 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000159; C:protein phosphatase type 2A complex; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
 GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.
 GO:0007050; P:cell cycle arrest; TAS:ProtInc.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0006470; P:protein dephosphorylation; ISS:UniProtKB. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13499; EF_hand_5 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS