CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005348
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable 26S proteasome non-ATPase regulatory subunit 3 
Protein Synonyms/Alias
 26S proteasome subunit S3; Diphenol oxidase A2 component; DOX-A2; Regulatory particle non-ATPase 3 
Gene Name
 Rpn3 
Gene Synonyms/Alias
 Dox-A2; CG42641 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
464YPPKSYGKDLESAEEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). 
Sequence Annotation
 DOMAIN 319 423 PCI.  
Keyword
 Complete proteome; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MTNATDIGAN DVEMEVDPTA ETLADEKKNQ DVAAVQEIRE QIRQIEKGVA SKESRFILRV 60
LRNLPNTRRK LNGVVFRNLA QSIYPAGADR EAAVALMPAV EKDATELPDV PKKQVATKAP 120
IAEVDAYFYL LLLVKLIDAS DLKRAGISAD ALMAKISIQN RRTLDLIGAK SYFYFSRVAE 180
LKNSLEGIRS FLHARLRTAT LRNDFEGQAV LINCLLRNYL HYALYDQADK LVKKSVYPES 240
ASNNEWARFL YYLGRIKAAK LEYSDAHKHL VQALRKSPQH AAIGFRQTVQ KLIIVVELLL 300
GNIPERVVFR QAGLRQSLGA YFQLTQAVRL GNLKRFGDVV SQYGPKFQLD HTFTLIIRLR 360
HNVIKTAIRS IGLSYSRISP QDIAKRLMLD SAEDAEFIVS KAIRDGVIEA TLDPAQNFMR 420
SKESTDIYST REPQLAFHER ISFCLNLHNQ SVKAMRYPPK SYGKDLESAE ERREREQQDL 480
ELAKEMAEDD EDGF 494 
Gene Ontology
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; ISS:FlyBase.
 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase.
 GO:0050790; P:regulation of catalytic activity; IEA:GOC.
 GO:0042176; P:regulation of protein catabolic process; IEA:InterPro. 
Interpro
 IPR013586; 26S_Psome_reg_C.
 IPR013143; PAM.
 IPR000717; PCI_dom.
 IPR011990; TPR-like_helical.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI
 PF08375; Rpn3_C 
SMART
 SM00753; PAM
 SM00088; PINT 
PROSITE
  
PRINTS