CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatocyte cell adhesion molecule 
Protein Synonyms/Alias
 Protein hepaCAM 
Gene Name
 Hepacam 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
292DQNDDRLKSEADTLPubiquitination[1]
307RSGEQERKNPMALYIubiquitination[1]
316PMALYILKDKDSSEPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). 
Sequence Annotation
 DOMAIN 34 142 Ig-like V-type.
 DOMAIN 148 234 Ig-like C2-type.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 CARBOHYD 35 35 N-linked (GlcNAc...) (Potential).
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 167 167 N-linked (GlcNAc...) (Potential).
 CARBOHYD 189 189 N-linked (GlcNAc...) (Potential).
 DISULFID 168 217 By similarity.  
Keyword
 Cell adhesion; Cell cycle; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Growth arrest; Growth regulation; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MKRERGALSR ASRALRLSPF VYLLLIQPVP LEGVNITSPV RLIHGTVGKS ALLSVQYSST 60
SSDKPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR LFENGSLLLS DLQLADEGTY 120
EVEISITDDT FTGEKTINLT VDVPISRPQV LVASTTVLEL SEAFTLNCSH ENGTKPSYTW 180
LKDGKPLLND SRMLLSPDQK VLTITRVLME DDDLYSCVVE NPISQVRSLP VKITVYRRSS 240
LYIILSTGGI FLLVTLVTVC ACWKPSKKSR KKRKLEKQNS LEYMDQNDDR LKSEADTLPR 300
SGEQERKNPM ALYILKDKDS SEPDENPATE PRSTTEPGPP GYSVSPPVPG RSPGLPIRSA 360
RRYPRSPARS PATGRTHTSP PRAPSSPGRS RSSSRSLRTA GVQRIREQDE SGQVEISA 418 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
 GO:0034613; P:cellular protein localization; IDA:MGI.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS