| Tag | Content |
|---|
| CPLM ID | CPLM-003862 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carboxylesterase 1C |
Protein Synonyms/Alias | Carboxyesterase ES-1; E1; ES-THET; Esterase-2; Liver carboxylesterase 1; Neutral retinyl ester hydrolase; NREH; Retinyl ester hydrolase; REH |
Gene Name | Ces1c |
Gene Synonyms/Alias | Es2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 368 | KMASSFLKRFSPNLN | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant (By similarity). |
Sequence Annotation | MOTIF 546 549 Prevents secretion from ER (Potential).
ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
ACT_SITE 340 340 Charge relay system (By similarity).
ACT_SITE 453 453 Charge relay system (By similarity).
CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
CARBOHYD 275 275 N-linked (GlcNAc...) (Potential).
CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
CARBOHYD 375 375 N-linked (GlcNAc...) (Potential).
CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
DISULFID 87 116 By similarity.
DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 549 AA |
Protein Sequence | MWLCALVWAS LAVCPIWGHP SSPPVVDTTK GKVLGKYVSL EGFTQPVAVF LGVPFAKPPL 60
GSLRFAPPEP AEPWSFVKNT TTYPPMCSQD GVVGKLLADM LSTGKESIPL EFSEDCLYLN 120
IYSPADLTKN SRLPVMVWIH GGGLIIGGAS PYSGLALSAH ENVVVVTIQY RLGIWGLFST 180
GDEHSRGNWA HLDQLAALRW VQDNIANFGG NPDSVTIFGE SAGGVSVSAL VLSPLAKNLF 240
HRAISESGVV LTTNLDKKNT QAVAQMIATL SGCNNTSSAA MVQCLRQKTE AELLELTVKL 300
DNTSMSTVID GVVLPKTPEE ILTEKSFNTV PYIVGFNKQE FGWIIPTMMG NLLSEGRMNE 360
KMASSFLKRF SPNLNISESV IPAIIEKYLR GTDDPAKKKE LLLDMFSDVF FGIPAVLMSR 420
SLRDAGAPTY MYEFQYRPSF VSDQRPQTVQ GDHGDEIFSV FGTPFLKEGA SEEETNLSKL 480
VMKFWANFAR NGNPNGEGLP HWPKYDQKEG YLQIGATTQQ AQKLKGEEVA FWTELLAKNP 540
PQTEHTEHT 549 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0004091; F:carboxylesterase activity; IDA:RGD. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |