CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044265
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Multidrug resistance-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 ABCC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145SDLWSLNKEDTSEQVubiquitination[1, 2, 3]
158QVVPVLVKNWKKECAubiquitination[1, 3]
179VKVVYSSKDPAQPKEubiquitination[1, 2, 3, 4]
189AQPKESSKVDANEEVubiquitination[1, 2, 3, 4]
202EVEALIVKSPQKEWNubiquitination[1, 3, 5, 6]
206LIVKSPQKEWNPSLFubiquitination[1, 5]
214EWNPSLFKVLYKTFGubiquitination[5]
295FVSGMRIKTAVIGAVubiquitination[1, 2]
305VIGAVYRKALVITNSubiquitination[2, 4]
315VITNSARKSSTVGEIubiquitination[1, 3, 4]
387AVMAMKTKTYQVAHMubiquitination[2]
395TYQVAHMKSKDNRIKubiquitination[1, 2, 3, 4]
397QVAHMKSKDNRIKLMubiquitination[2]
402KSKDNRIKLMNEILNubiquitination[1, 2, 3, 5]
412NEILNGIKVLKLYAWubiquitination[1, 2, 3, 5]
424YAWELAFKDKVLAIRubiquitination[1, 3]
535SIERRPVKDGGGTNSubiquitination[1, 2, 3, 4]
672VNLSGGQKQRVSLARubiquitination[2]
703AVDAHVGKHIFENVIubiquitination[1]
713FENVIGPKGMLKNKTubiquitination[1, 2, 3, 5]
800TGVSGPGKEAKQMENubiquitination[3]
803SGPGKEAKQMENGMLubiquitination[1, 2, 3, 4, 6]
817LVTDSAGKQLQRQLSubiquitination[1, 2, 3, 5, 6]
845NSTAELQKAEAKKEEubiquitination[1, 2, 3]
861WKLMEADKAQTGQVKubiquitination[1, 2]
987NLVNRFSKELDTVDSubiquitination[1, 3]
1090FIHQSDLKVDENQKAubiquitination[1, 2, 3, 4, 6]
1096LKVDENQKAYYPSIVubiquitination[1, 2, 3]
1174IVAVERLKEYSETEKubiquitination[1, 2, 3]
1181KEYSETEKEAPWQIQubiquitination[1, 2, 3]
1231VTINGGEKVGIVGRTubiquitination[2]
1242VGRTGAGKSSLTLGLubiquitination[2, 3, 6]
1278GLHDLRFKITIIPQDubiquitination[1, 2, 3]
1411TRVIVLDKGEIQEYGubiquitination[1, 2, 3, 4, 7]
1435GLFYSMAKDAGLV**ubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1440 AA 
Protein Sequence
XAPVFLVSPT LLGITMLLAT FLIQLERRKG VQSSGIMLTF WLVALVCALA ILRSKIMTAL 60
KEDAQVDLFR DITFYVYFSL LLIQLVLSCF SDRSPLFSET IHDPNPCPES SASFLSRITF 120
WWITGLIVRG YRQPLEGSDL WSLNKEDTSE QVVPVLVKNW KKECAKTRKQ PVKVVYSSKD 180
PAQPKESSKV DANEEVEALI VKSPQKEWNP SLFKVLYKTF GPYFLMSFFF KAIHDLMMFS 240
GPQILKLLIK FVNDTKAPDW QGYFYTVLLF VTACLQTLVL HQYFHICFVS GMRIKTAVIG 300
AVYRKALVIT NSARKSSTVG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV ILALYLLWLN 360
LGPSVLAGVA VMVLMVPVNA VMAMKTKTYQ VAHMKSKDNR IKLMNEILNG IKVLKLYAWE 420
LAFKDKVLAI RQEELKVLKK SAYLSAVGTF TWVCTPFLVA LCTFAVYVTI DENNILDAQT 480
AFVSLALFNI LRFPLNILPM VISSIVQASV SLKRLRIFLS HEELEPDSIE RRPVKDGGGT 540
NSITVRNATF TWARSDPPTL NGITFSIPEG ALVAVVGQVG CGKSSLLSAL LAEMDKVEGH 600
VAIKGSVAYV PQQAWIQNDS LRENILFGCQ LEEPYYRSVI QACALLPDLE ILPSGDRTEI 660
GEKGVNLSGG QKQRVSLARA VYSNADIYLF DDPLSAVDAH VGKHIFENVI GPKGMLKNKT 720
RILVTHSMSY LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN 780
GSTVMDEEEA GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST 840
AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL FMCNHVSALA 900
SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF GYSMAVSIGG ILASRCLHVD 960
LLHSILRSPM SFFERTPSGN LVNRFSKELD TVDSMIPEVI KMFMGSLFNV IGACIVILLA 1020
TPIAAIIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ 1080
ERFIHQSDLK VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG 1140
LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET APPSSWPQVG 1200
RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA GKSSLTLGLF RINESAEGEI 1260
IIDGINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF SQYSDEEVWT SLELAHLKDF 1320
VSALPDKLDH ECAEGGENLS VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST 1380
IRTQFEDCTV LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV 1440 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS