UniProt Accession

 ALAT2_MOUSE; Q8BGT5; Q8BVY7; Q8K1J3 

Genbank Protein ID

 AK033424; AK075894; AK076250; AK082030; BC034219; BK005128 

Genbank Nucleotide ID

 BAC28282.1; BAC36035.1; BAC36274.1; BAC38395.1; AAH34219.1; DAA05290.1 

Protein Name

 Alanine aminotransferase 2 

Protein Synonyms/Alias

 ALT2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2 

Gene Name

 Gpt2 

Gene Synonyms/Alias

 Aat2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	ESMNPQVKAVEYAVR	ubiquitination	[1]
85	ELQRGIKKPFTEVIR	ubiquitination	[1]
203	LLVSGGGKSRTGVMI	ubiquitination	[1]
255	RRALRQAKDHCDPKV	acetylation	[2, 3]
261	AKDHCDPKVLCIINP	acetylation	[2, 3]
368	EIKGQLVKLLSVRLC	ubiquitination	[1]
405	FEQFSREKEFVLGNL	acetylation	[4]
405	FEQFSREKEFVLGNL	ubiquitination	[1]
414	FVLGNLAKKAKLTED	acetylation	[2, 3, 4]
449	PRILIPAKAVEAAQS	acetylation	[2, 4]
458	VEAAQSHKMAPDMFY	acetylation	[3]
458	VEAAQSHKMAPDMFY	ubiquitination	[1]
502	TILPPVDKLKTVLHK	acetylation	[3]
504	LPPVDKLKTVLHKVK	acetylation	[2, 3, 4]
509	KLKTVLHKVKDFHLK	acetylation	[2, 3]
511	KTVLHKVKDFHLKFL	acetylation	[2, 3, 4]
516	KVKDFHLKFLEQYS*	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate (By similarity). 

Sequence Annotation

 MOD_RES 340 340 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Aminotransferase; Complete proteome; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 522 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0042851; P:L-alanine metabolic process; ISS:UniProtKB. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

  

PRINTS