| Tag | Content |
|---|
| CPLM ID | CPLM-009927 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc fingers and homeoboxes protein 1 |
Protein Synonyms/Alias | |
Gene Name | Zhx1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 692 | PSAEEYDKLAEESGL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co- repressor proteins (By similarity). |
Sequence Annotation | ZN_FING 70 93 C2H2-type 1.
ZN_FING 102 125 C2H2-type 2.
DNA_BIND 284 346 Homeobox 1.
DNA_BIND 464 526 Homeobox 2.
DNA_BIND 569 630 Homeobox 3.
DNA_BIND 660 722 Homeobox 4.
DNA_BIND 777 832 Homeobox 5.
REGION 272 564 Required for interaction with NFYA (By
REGION 272 432 Required for dimerization (By
REGION 734 768 Required for nuclear localization (By
REGION 831 873 Required for repressor activity (By
MOD_RES 45 45 Phosphoserine.
MOD_RES 47 47 Phosphoserine.
MOD_RES 48 48 Phosphoserine.
MOD_RES 647 647 Phosphoserine.
MOD_RES 648 648 Phosphoserine. |
Keyword | Complete proteome; DNA-binding; Homeobox; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 873 AA |
Protein Sequence | MASRRKSTTP CMVLASEQDP DLELISDLDE GPPILTPVEN AKAESVSSDE EVHGSVDSDN 60
QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS SYVCVECNFL TKRYDALSEH 120
NLKYHPGEEN FKLTMVKRNN QTIFEQTIND LTFDGSFVKE ENTEQGESID VSSSGISISK 180
TPIMKMMKNK VENKRITVHH NSAEGTSEEK ENGVKASQEE NAESVSSSAL ESNTSTSTIN 240
RVHPSPASTV VTPTAVLPGL AQVITAVSAQ QNSNLLPKVL IPVNSIPTYN AALDNNPLLL 300
NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE ARRKQFNGTV 360
HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ VAGTNTLPVT APIALTVAGV 420
PNQTNVQKSQ VPAAQPATDT KPATAAVPSS PSVRPEAALV NPDSFGIRAK KTKEQLAELK 480
VSYLKNQFPH DSEIIRLMKI TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSATIII 540
DSSDETPEPP AAAASQQKQS WNPFPDFAPQ KFKEKTAEQL RALQASFLNS SVLTDEEVNR 600
LRAQTKLTRR EIDAWFTEKN KTKALKDEKI EVDESNVGSS KEEPGESSPG DETVAPKSGG 660
TGKICKKTPE QLHMLKSAFV RTQWPSAEEY DKLAEESGLA RTDIVSWFGD TRYAWKNGNL 720
KWYYYYQSSN SSSLNGLSSL RRRGRGRPKG RGRGRPRGRP RGGKRMNTWD RVPSLIKFKT 780
GTAILKDYYL KHKFLNEQDL DELVNRSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE 840
VVDDQEEDEE ETDDSDTWEP PRHVKRKLSK SDD 873 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara. GO:0003714; F:transcription corepressor activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |