UniProt Accession

 TPM3L_HUMAN; A6NL28; A4D186 

Genbank Protein ID

 AC004079; CH236948 

Genbank Nucleotide ID

 EAL24230.1 

Protein Name

 Putative tropomyosin alpha-3 chain-like protein 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	TMEEVKCKIQVLQQQ	ubiquitination	[1, 2]
75	IENQAALKDEEKMEL	acetylation	[2]
75	IENQAALKDEEKMEL	ubiquitination	[1]
79	AALKDEEKMELQEIQ	ubiquitination	[2]
88	ELQEIQLKEAKHIAE	acetylation	[3]
88	ELQEIQLKEAKHIAE	ubiquitination	[2]
91	EIQLKEAKHIAEEAD	acetylation	[2]
91	EIQLKEAKHIAEEAD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells (By similarity). 

Sequence Annotation

  

Keyword

 Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.