| Tag | Content |
|---|
| CPLM ID | CPLM-019645 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 382 |
Protein Synonyms/Alias | KRAB/zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1 |
Gene Name | ZNF382 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 58 | AKPDMIRKLEQGEEL | ubiquitination | [1] | | 144 | KPDGKVLKNISELVI | ubiquitination | [1] | | 518 | QKTHTGEKPYECKQC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Functions as a sequence-specific transcriptional repressor (By similarity). |
Sequence Annotation | DOMAIN 7 78 KRAB.
ZN_FING 212 234 C2H2-type 1; degenerate.
ZN_FING 296 318 C2H2-type 2.
ZN_FING 324 346 C2H2-type 3.
ZN_FING 352 374 C2H2-type 4.
ZN_FING 380 402 C2H2-type 5.
ZN_FING 408 430 C2H2-type 6.
ZN_FING 436 458 C2H2-type 7.
ZN_FING 464 486 C2H2-type 8.
ZN_FING 492 514 C2H2-type 9.
ZN_FING 520 542 C2H2-type 10.
REGION 1 105 Mediates interaction with TRIM28 (By
REGION 5 46 Represses transcription (By similarity).
REGION 70 211 Represses transcription (By similarity).
REGION 296 550 Required for transcriptional repression |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 550 AA |
Protein Sequence | MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM AKPDMIRKLE 60
QGEELWTQRI FPSYSYLEED GKTEDVLVKF KEYQDRHSRP LIFINHKKLI KERSNIYGKT 120
FTLGKNRISK TILCEYKPDG KVLKNISELV IRNISPIKEK FGDSTGWEKS LLNTKHEKIH 180
PAVNLHKQTE RVLSGKQELI QHQKVQAPEQ PFDHNECEKS FLMKGMLFTH TRAHRGERTF 240
EYNKDGIAFI EKSSLSVHPS NLMEKKPSAY NKYGKFLCRK PVFIMPQRPQ TEEKPFHCPY 300
CGNNFRRKSY LIEHQRIHTG EKPYVCNQCG KAFRQKTALT LHEKTHIEGK PFICIDCGKS 360
FRQKATLTRH HKTHTGEKAY ECPQCGSAFR KKSYLIDHQR THTGEKPYQC NECGKAFIQK 420
TTLTVHQRTH TGEKPYICNE CGKSFCQKTT LTLHQRIHTG EKPYICNECG KSFRQKAILT 480
VHHRIHTGEK SNGCPQCGKA FSRKSNLIRH QKTHTGEKPY ECKQCGKFFS CKSNLIVHQK 540
THKVETTGIQ 550 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |