UniProt Accession

 RAB12_HUMAN; Q6IQ22; A6NEF5; Q4KMQ3 

Genbank Protein ID

 AP001793; CH471113; BC050338; BC071600; BC098407 

Genbank Nucleotide ID

 EAX01616.1; AAH71600.2; AAH98407.1 

Protein Name

 Ras-related protein Rab-12 

Protein Synonyms/Alias

  

Gene Name

 RAB12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
172	ITRQQGEKFAQQITG	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (By similarity). 

Sequence Annotation

 NP_BIND 49 57 GTP.
 NP_BIND 97 101 GTP (By similarity).
 NP_BIND 155 159 GTP.
 NP_BIND 187 188 GTP.
 MOTIF 71 79 Effector region (By similarity).
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 106 106 Phosphoserine (By similarity).
 LIPID 243 243 S-geranylgeranyl cysteine (By
 LIPID 244 244 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Complete proteome; Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0044257; P:cellular protein catabolic process; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.