| Tag | Content |
|---|
| CPLM ID | CPLM-019378 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mastermind-like protein 3 |
Protein Synonyms/Alias | Mam-3 |
Gene Name | MAML3 |
Gene Synonyms/Alias | KIAA1816 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 599 | ILTYGNTKPLTHFNA | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. |
Sequence Annotation | MOD_RES 599 599 N6-acetyllysine. |
Keyword | Acetylation; Activator; Complete proteome; Notch signaling pathway; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1134 AA |
Protein Sequence | MGDFAAPAAA ANGSSICINS SLNSSLGGAG IGVNNTPNST PAAPSSNHPA AGGCGGSGGP 60
GGGSAAVPKH STVVERLRQR IEGCRRHHVN CENRYQQAQV EQLELERRDT VSLYQRTLEQ 120
RAKKSGAGTG KQQHPSKPQQ DAEAASAEQR NHTLIMLQET VKRKLEGARS PLNGDQQNGA 180
CDGNFSPTSK RIRKDISAGM EAINNLPSNM PLPSASPLHQ LDLKPSLPLQ NSGTHTPGLL 240
EDLSKNGRLP EIKLPVNGCS DLEDSFTILQ SKDLKQEPLD DPTCIDTSET SLSNQNKLFS 300
DINLNDQEWQ ELIDELANTV PEDDIQDLFN EDFEEKKEPE FSQPATETPL SQESASVKSD 360
PSHSPFAHVS MGSPQARPSS SGPPFSTVST ATSLPSVAST PAAPNPASSP ANCAVQSPQT 420
PNQAHTPGQA PPRPGNGYLL NPAAVTVAGS ASGPVAVPSS DMSPAEQLKQ MAAQQQQRAK 480
LMQQKQQQQQ QQQQQQQQQQ QQQQQQHSNQ TSNWSPLGPP SSPYGAAFTA EKPNSPMMYP 540
QAFNNQNPIV PPMANNLQKT TMNNYLPQNH MNMINQQPNN LGTNSLNKQH NILTYGNTKP 600
LTHFNADLSQ RMTPPVANPN KNPLMPYIQQ QQQQQQQQQQ QQQQQQPPPP QLQAPRAHLS 660
EDQKRLLLMK QKGVMNQPMA YAALPSHGQE QHPVGLPRTT GPMQSSVPPG SGGMVSGASP 720
AGPGFLGSQP QAAIMKQMLI DQRAQLIEQQ KQQFLREQRQ QQQQQQQQIL AEQQLQQSHL 780
PRQHLQPQRN PYPVQQVNQF QGSPQDIAAV RSQAALQSMR TSRLMAQNAG MMGIGPSQNP 840
GTMATAAAQS EMGLAPYSTT PTSQPGMYNM STGMTQMLQH PNQSGMSITH NQAQGPRQPA 900
SGQGVGMVSG FGQSMLVNSA ITQQHPQMKG PVGQALPRPQ APPRLQSLMG TVQQGAQSWQ 960
QRSLQGMPGR TSGELGPFNN GASYPLQAGQ PRLTKQHFPQ GLSQSVVDAN TGTVRTLNPA 1020
AMGRQMMPSL PGQQGTSQAR PMVMSGLSQG VPGMPAFSQP PAQQQIPSGS FAPSSQSQAY 1080
ERNAPQDVSY NYSGDGAGGS FPGLPDGADL VDSIIKGGPG DEWMQELDEL FGNP 1134 |
Gene Ontology | GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003713; F:transcription coactivator activity; IDA:UniProtKB. GO:0007219; P:Notch signaling pathway; IDA:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |