CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plexin-A1 
Protein Synonyms/Alias
  
Gene Name
 PLXNA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171VGTPIDGKSEYFPTLubiquitination[1]
359SCYRGEGKLSLPWLLubiquitination[1]
1018QLTNPEVKYNYTEDPubiquitination[2]
1395LLSDLIEKNLESKNHubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1873 AA 
Protein Sequence
MWAEAGLPRA GGGSQPPFRT FSASDWGLTH LVVHEQTGEV YVGAVNRIYK LSGNLTLLRA 60
HVTGPVEDNE KCYPPPSVQS CPHGLGSTDN VNKLLLLDYA ANRLLACGSA SQGICQFLRL 120
DDLFKLGEPH HRKEHYLSSV QEAGSMAGVL IAGPPGQGQA KLFVGTPIDG KSEYFPTLSS 180
RRLMANEEDA DMFGFVYQDE FVSSQLKIPS DTLSKFPAFD IYYVYSFRSE QFVYYLTLQL 240
DTQLTSPDAA GEHFFTSKIV RLCVDDPKFY SYVEFPIGCE QAGVEYRLVQ DAYLSRPGRA 300
LAHQLGLAED EDVLFTVFAQ GQKNRVKPPK ESALCLFTLR AIKEKIKERI QSCYRGEGKL 360
SLPWLLNKEL GCINSPLQID DDFCGQDFNQ PLGGTVTIEG TPLFVDKDDG LTAVAAYDYR 420
GRTVVFAGTR SGRIRKILVD LSNPGGRPAL AYESVVAQEG SPILRDLVLS PNHQYLYAMT 480
EKQVTRVPVE SCVQYTSCEL CLGSRDPHCG WCVLHSICSR RDACERADEP QRFAADLLQC 540
VQLTVQPRNV SVTMSQVPLV LQAWNVPDLS AGVNCSFEDF TESESVLEDG RIHCRSPSAR 600
EVAPITRGQG DQRVVKLYLK SKETGKKFAS VDFVFYNCSV HQSCLSCVNG SFPCHWCKYR 660
HVCTHNVADC AFLEGRVNVS EDCPQILPST QIYVPVGVVK PITLAARNLP QPQSGQRGYE 720
CLFHIPGSPA RVTALRFNSS SLQCQNSSYS YEGNDVSDLP VNLSVVWNGN FVIDNPQNIQ 780
AHLYKCPALR ESCGLCLKAD PRFECGWCVA ERRCSLRHHC AADTPASWMH ARHGSSRCTD 840
PKILKLSPET GPRQGGTRLT ITGENLGLRF EDVRLGVRVG KVLCSPVESE YISAEQIVCE 900
IGDASSVRAH DALVEVCVRD CSPHYRALSP KRFTFVTPTF YRVSPSRGPL SGGTWIGIEG 960
SHLNAGSDVA VSVGGRPCSF SWRNSREIRC LTPPGQSPGS APIIININRA QLTNPEVKYN 1020
YTEDPTILRI DPEWSINSGG TLLTVTGTNL ATVREPRIRA KYGGIERENG CLVYNDTTMV 1080
CRAPSVANPV RSPPELGERP DELGFVMDNV RSLLVLNSTS FLYYPDPVLE PLSPTGLLEL 1140
KPSSPLILKG RNLLPPAPGN SRLNYTVLIG STPCTLTVSE TQLLCEAPNL TGQHKVTVRA 1200
GGFEFSPGTL QVYSDSLLTL PAIVGIGGGG GLLLLVIVAV LIAYKRKSRD ADRTLKRLQL 1260
QMDNLESRVA LECKEAFAEL QTDIHELTND LDGAGIPFLD YRTYAMRVLF PGIEDHPVLK 1320
EMEVQANVEK SLTLFGQLLT KKHFLLTFIR TLEAQRSFSM RDRGNVASLI MTALQGEMEY 1380
ATGVLKQLLS DLIEKNLESK NHPKLLLRRT ESVAEKMLTN WFTFLLYKFL KECAGEPLFM 1440
LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIDYKTL TLNCVNPENE NAPEVPVKGL 1500
DCDTVTQAKE KLLDAAYKGV PYSQRPKAAD MDLEWRQGRM ARIILQDEDV TTKIDNDWKR 1560
LNTLAHYQVT DGSSVALVPK QTSAYNISNS STFTKSLSRY ESMLRTASSP DSLRSRTPMI 1620
TPDLESGTKL WHLVKNHDHL DQREGDRGSK MVSEIYLTRL LATKGTLQKF VDDLFETIFS 1680
TAHRGSALPL AIKYMFDFLD EQADKHQIHD ADVRHTWKSN CLPLRFWVNV IKNPQFVFDI 1740
HKNSITDACL SVVAQTFMDS CSTSEHKLGK DSPSNKLLYA KDIPNYKSWV ERYYADIAKM 1800
PAISDQDMSA YLAEQSRLHL SQFNSMSALH EIYSYITKYK DEILAALEKD EQARRQRLRS 1860
KLEQVVDTMA LSS 1873 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0017154; F:semaphorin receptor activity; IEA:Compara.
 GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Compara. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR013548; Plexin_cytoplasmic_RasGAP_dom.
 IPR002165; Plexin_repeat.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08337; Plexin_cytopl
 PF01437; PSI
 PF01403; Sema
 PF01833; TIG 
SMART
 SM00429; IPT
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS