CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026369
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Shmt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
103YSEGYPGKRYYGGAEacetylation[1]
181HGYMSDVKRISATSIacetylation[1]
269KVIPSPFKYADIVTTacetylation[1]
280IVTTTTHKTLRGARSacetylation[1]
302GVRTVDPKTGQEIPYacetylation[1]
367AMADALLKRGYSLVSacetylation[1]
459VNIGLEVKRKTAKLQacetylation[1]
464EVKRKTAKLQDFKSFacetylation[1]
469TAKLQDFKSFLLKDPacetylation[1]
474DFKSFLLKDPETSQRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Interconversion of serine and glycine (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MVPFSLLRTT RPLQRCGQLV CMAARAQHSE VAQKQAGEAA GGWTGQESLS DSDPEIWELL 60
QREKDRQCRG LELIASENFC SRAALEALGS CLNNKYSEGY PGKRYYGGAE VVDEIELLCQ 120
RRALEAFDLD PAQWGVNVQP YSGSPANLAA YTALLQPHDR IMGLDLPDGG HLTHGYMSDV 180
KRISATSIFF ESMPYKLNPQ TGLIDYDQLA LTARLFRPRL IIAGTSAYAR LIDYARMREV 240
CDEVKAHLLA DMAHISGLVA AKVIPSPFKY ADIVTTTTHK TLRGARSGLI FYRKGVRTVD 300
PKTGQEIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY SLQVLRNAQA 360
MADALLKRGY SLVSGGTDTH LVLVDLRPKG LDGARAERVL ELVSITANKN TCPGDRSAIT 420
PGGLRLGAPA LTSRQFREDD FRRVVDFIDE GVNIGLEVKR KTAKLQDFKS FLLKDPETSQ 480
RLANLRQQVE QFARGFPMPG FDER 504 
Gene Ontology
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
 GO:0005759; C:mitochondrial matrix; IDA:RGD.
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0016597; F:amino acid binding; IPI:RGD.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0008732; F:L-allo-threonine aldolase activity; IDA:RGD.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0030170; F:pyridoxal phosphate binding; IDA:RGD.
 GO:0019264; P:glycine biosynthetic process from serine; IDA:RGD.
 GO:0006564; P:L-serine biosynthetic process; IDA:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 
Interpro
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 
Pfam
 PF00464; SHMT 
SMART
  
PROSITE
 PS00096; SHMT 
PRINTS