UniProt Accession

 MK13_HUMAN; O15264; O14739; O15124; Q6FI46; Q9UNU0 

Genbank Protein ID

 Y10488; U93232; AF015256; AF004709; AF092535; AF100546; BT007221; CR536490; Z95152; CH471081; BC000433; BC001641; BC004428 

Genbank Nucleotide ID

 CAA71512.1; AAB87639.1; AAC51758.1; AAC51374.1; AAD23377.1; AAF36772.1; AAP35885.1; CAG38729.1; CAB08438.1; EAX03875.1; AAH00433.1; AAH01641.1; AAH04428.1 

Protein Name

 Mitogen-activated protein kinase 13 

Protein Synonyms/Alias

 MAP kinase 13; MAPK 13; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4 

Gene Name

 MAPK13 

Gene Synonyms/Alias

 PRKM13; SAPK4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
226	GKTLFKGKDYLDQLT	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. 

Sequence Annotation

 DOMAIN 25 308 Protein kinase.
 NP_BIND 31 39 ATP (By similarity).
 MOTIF 180 182 TXY.
 ACT_SITE 150 150 Proton acceptor (By similarity).
 BINDING 54 54 ATP (By similarity).
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 180 180 Phosphothreonine; by MAP2K3, MAP2K4,
 MOD_RES 182 182 Phosphotyrosine; by MAP2K3, MAP2K4,
 MOD_RES 350 350 Phosphoserine.  

Keyword

 3D-structure; ATP-binding; Cell cycle; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Stress response; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004707; F:MAP kinase activity; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL.
 GO:0032755; P:positive regulation of interleukin-6 production; IMP:BHF-UCL.
 GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006970; P:response to osmotic stress; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR003527; MAP_kinase_CS.
 IPR008352; MAPK_p38.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS01351; MAPK
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS

 PR01773; P38MAPKINASE.