UniProt Accession

 E5RGW5_HUMAN; E5RGW5 

Genbank Protein ID

 AC083973 

Genbank Nucleotide ID

  

Protein Name

 Inhibitor of nuclear factor kappa-B kinase subunit beta 

Protein Synonyms/Alias

  

Gene Name

 IKBKB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	TGEQIAIKQCRQELS	ubiquitination	[1]
106	CQGGDLRKYLNQFEN	ubiquitination	[1, 2]
147	RIIHRDLKPENIVLQ	acetylation	[3]
147	RIIHRDLKPENIVLQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008384; F:IkappaB kinase activity; IEA:Compara.
 GO:0001782; P:B cell homeostasis; IEA:Compara.
 GO:0007252; P:I-kappaB phosphorylation; IEA:GOC.
 GO:2001259; P:positive regulation of cation channel activity; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50053; UBIQUITIN_2 

PRINTS