CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011612
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon-activable protein 205-B 
Protein Synonyms/Alias
 Ifi-205-B; Interferon-inducible protein p205-B; Myeloid cell nuclear differentiation antigen; Protein D3 
Gene Name
 Ifi205b 
Gene Synonyms/Alias
 Mnda 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
210ILSAKNQKSQPQNQNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. 
Sequence Annotation
 DOMAIN 1 88 DAPIN.
 REPEAT 129 135 1.
 REPEAT 136 142 2.
 REPEAT 143 149 3.
 REPEAT 150 156 4.
 DOMAIN 213 413 HIN-200.
 REGION 129 177 4 X 7 AA tandem repeats of T-S-T-A-Q-A-  
Keyword
 3D-structure; Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN MMEEKFPADS 60
GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ EAGPATPTST TSHMLASERG 120
ETSATQEETS TAQAGTSTAQ AGTSTAQAGT STAQKRKSMR EEETGVKKSK AAKEPDQPPC 180
CEEPTAMCQS PILHSSSSAS SNILSAKNQK SQPQNQNIPR GAVLHSEPLT VMVLTATDPF 240
EYESPEHEVK NMFHATVATV SQYFHVKVFN IDLKEKFTKN NFITISNYFE SKGILEINET 300
SSVLEAAPKQ MIEVPNCITR NANASPKICD IQKGTSGTVF YGVFTLHKKK VKTQNTSYEI 360
KDGSGSIEVV GSGQWHNINC KEGDKLHLFC FHLKRERGQP KLVCGDHSFV KVTKAGKKKE 420
ASTVQ 425 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR004020; DAPIN.
 IPR004021; HIN200/IF120x.
 IPR012340; NA-bd_OB-fold. 
Pfam
 PF02760; HIN
 PF02758; PYRIN 
SMART
  
PROSITE
 PS50824; DAPIN
 PS50834; HIN_200 
PRINTS