UniProt Accession

 DCXR_HUMAN; Q7Z4W1; Q9BTZ3; Q9UHY9 

Genbank Protein ID

 AB013846; AF515623; AF515624; AF515625; AF113123; AF139841; BT006881; BC001470; BC003018 

Genbank Nucleotide ID

 BAB64299.1; AAN59786.1; AAO15991.1; AAM54026.1; AAF14864.1; AAP97273.1; AAP35527.1; AAH01470.1; AAH03018.1 

Protein Name

 L-xylulose reductase 

Protein Synonyms/Alias

 XR; Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H 

Gene Name

 DCXR 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	VLVTGAGKGIGRGTV	ubiquitination	[1, 2, 3]
153	HSVYCSTKGALDMLT	ubiquitination	[3]
161	GALDMLTKVMALELG	ubiquitination	[1, 3, 4]
171	ALELGPHKIRVNAVN	ubiquitination	[1, 3, 4]
196	ATWSDPHKAKTMLNR	ubiquitination	[1]
198	WSDPHKAKTMLNRIP	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. 

Sequence Annotation

 NP_BIND 11 40 NADP.
 ACT_SITE 149 149 Proton acceptor.
 BINDING 136 136 Substrate.
 BINDING 153 153 NADP.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Xylose metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005903; C:brush border; IEA:Compara.
 GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0050038; F:L-xylulose reductase (NADP+) activity; IDA:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:UniProtKB.
 GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
 GO:0006006; P:glucose metabolic process; IDA:UniProtKB.
 GO:0006739; P:NADP metabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0005997; P:xylulose metabolic process; IDA:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.