UniProt Accession

 PTK7_HUMAN; Q13308; A8K974; B7Z477; E9PFZ5; Q13417; Q5T650; Q6IQ54; Q8NFA5; Q8NFA6; Q8NFA7; Q8NFA8 

Genbank Protein ID

 U33635; U40271; AF447176; AF447157; AF447158; AF447162; AF447164; AF447167; AF447170; AF447171; AF447173; AF447174; AF447175; AF531868; AF531869; AF531870; AF531871; AF531872; AK291016; AK292589; AK296953; AL355385; CH471081; CH471081; CH471081; CH471081; CH471081; BC071557 

Genbank Nucleotide ID

 AAA87565.1; AAC50484.2; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAL39062.1; AAN04862.1; AAN04863.1; AAN04864.1; AAN04865.1; AAN04866.1; BAF83705.1; BAF85278.1; BAH12463.1; CAI13783.1; EAX04154.1; EAX04155.1; EAX04156.1; EAX04158.1; EAX04160.1; AAH71557.1 

Protein Name

 Inactive tyrosine-protein kinase 7 

Protein Synonyms/Alias

 Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7 

Gene Name

 PTK7 

Gene Synonyms/Alias

 CCK4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	EAGPVVLKHPASEAE	ubiquitination	[1]
181	SNHTVSSKERNLTLR	ubiquitination	[1, 2, 3]
636	DRILDPTKLGPRMHI	ubiquitination	[1, 2]
804	QPITTLGKSEFGEVF	ubiquitination	[1]
830	AETLVLVKSLQSKDE	ubiquitination	[4]
835	LVKSLQSKDEQQQLD	ubiquitination	[1]
898	KSKDEKLKSQPLSTK	ubiquitination	[1]
929	SNNRFVHKDLAARNC	ubiquitination	[5]
1069	GDSTVDSKP******	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. 

Sequence Annotation

 DOMAIN 31 120 Ig-like C2-type 1.
 DOMAIN 128 218 Ig-like C2-type 2.
 DOMAIN 225 317 Ig-like C2-type 3.
 DOMAIN 309 407 Ig-like C2-type 4.
 DOMAIN 412 497 Ig-like C2-type 5.
 DOMAIN 503 586 Ig-like C2-type 6.
 DOMAIN 578 680 Ig-like C2-type 7.
 DOMAIN 796 1066 Protein kinase; inactive.
 REGION 794 1070 Interaction with CTNNB1.
 CARBOHYD 116 116 N-linked (GlcNAc...).
 CARBOHYD 175 175 N-linked (GlcNAc...).
 CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 268 268 N-linked (GlcNAc...).
 CARBOHYD 283 283 N-linked (GlcNAc...).
 CARBOHYD 405 405 N-linked (GlcNAc...) (Potential).
 CARBOHYD 463 463 N-linked (GlcNAc...) (Potential).
 CARBOHYD 567 567 N-linked (GlcNAc...) (Potential).
 CARBOHYD 646 646 N-linked (GlcNAc...).
 DISULFID 53 101 By similarity.
 DISULFID 150 200 By similarity.
 DISULFID 246 301 By similarity.
 DISULFID 343 391 By similarity.
 DISULFID 433 481 By similarity.
 DISULFID 524 570 By similarity.
 DISULFID 613 664 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1070 AA 

Protein Sequence

Gene Ontology

 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; TAS:ProtInc.
 GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.
 GO:0003401; P:axis elongation; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0060026; P:convergent extension; IEA:Compara.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0060484; P:lung-associated mesenchyme development; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 

Pfam

 PF07679; I-set
 PF07714; Pkinase_Tyr 

SMART

 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 

PROSITE

 PS50835; IG_LIKE
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 

PRINTS

 PR00109; TYRKINASE.