CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036933
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tankyrase-1 
Protein Synonyms/Alias
  
Gene Name
 TNKS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90DLADPSAKAVLTGEYubiquitination[1]
270ADLAKVKKTLALEIIubiquitination[2]
346VLHKHGAKMNALDTLubiquitination[1, 3]
422YRLLEASKAGDLETVubiquitination[2, 3]
430AGDLETVKQLCSSQNubiquitination[3]
513VNVADLWKFTPLHEAubiquitination[3]
525HEAAAKGKYEICKLLubiquitination[3]
530KGKYEICKLLLKHGAubiquitination[3, 4]
534EICKLLLKHGADPTKubiquitination[2, 3]
584GCLARVQKLCTPENIubiquitination[2, 3]
783GAAGTERKEGEVAGLubiquitination[3]
844GHRHKLIKGVERLLGubiquitination[2]
1001GTGCPTHKDRSCYICubiquitination[2, 3]
1021FCRVTLGKSFLQFSTubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1090 AA 
Protein Sequence
MGANVHARDD GGLIPLHNAC SFGHAEVVSL LLCQGADPNA RDNWNYTPLH EAAIKGKIDV 60
CIVLLQHGAD PNIRNTDGKS ALDLADPSAK AVLTGEYKKD ELLEAARSGN EEKLMALLTP 120
LNVNCHASDG RKSTPLHLAA GYNRVRIVQL LLQHGADVHA KDKGGLVPLH NACSYGHYEV 180
TELLLKHGAC VNAMDLWQFT PLHEAASKNR VEVCSLLLSH GADPTLVNCH GKSAVDMAPT 240
PELRERLTYE FKGHSLLQAA READLAKVKK TLALEIINFK QPQSHETALH CAVASLHPKR 300
KQVTELLLRK GANVNEKNKD FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL DTLGQTALHR 360
AALAGHLQTC RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ ILSESTPIRT SDVDYRLLEA 420
SKAGDLETVK QLCSSQNVNC RDLEGRHSTP LHFAAGYNRV SVVEYLLHHG ADVHAKDKGG 480
LVPLHNACSY GHYEVAELLV RHGASVNVAD LWKFTPLHEA AAKGKYEICK LLLKHGADPT 540
KKNRDGNTPL DLVKEGDTDI QDLLRGDAAL LDAAKKGCLA RVQKLCTPEN INCRDTQGRN 600
STPLHLAAGY NNLEVAEYLL EHGADVNAQD KGGLIPLHNA ASYGHVDIAA LLIKYNTCVN 660
ATDKWAFTPL HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ TPLDLATADD IRALLIDAMP 720
PEALPTCFKP QATVVSASLI SPASTPSCLS AASSIDNLTG PLAELAVGGA SNAGDGAAGT 780
ERKEGEVAGL DMNISQFLKS LGLEHLRDIF ETEQITLDVL ADMGHEELKE IGINAYGHRH 840
KLIKGVERLL GGQQGTNPYL TFHCVNQGTI LLDLAPEDKE YQSVEEEMQS TIREHRDGGN 900
AGGIFNRYNV IRIQKVVNKK LRERFCHRQK EVSEENHNHH NERMLFHGSP FINAIIHKGF 960
DERHAYIGGM FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH KDRSCYICHR QMLFCRVTLG 1020
KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG EQAYPEYLIT YQIMKPEAPS 1080
QTATAAEQKT 1090 
Gene Ontology
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF00644; PARP
 PF07647; SAM_2 
SMART
 SM00248; ANK
 SM00454; SAM 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS51059; PARP_CATALYTIC
 PS50105; SAM_DOMAIN 
PRINTS
 PR01415; ANKYRIN.