| Tag | Content |
|---|
| CPLM ID | CPLM-004445 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-aminobutyric acid receptor subunit alpha-6 |
Protein Synonyms/Alias | GABA(A) receptor subunit alpha-6 |
Gene Name | Gabra6 |
Gene Synonyms/Alias | Gabra-6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 389 | VPSSEASKALSRTPI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Sequence Annotation | CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
DISULFID 156 170 By similarity. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MVLLLPWLFI ILWLENAQAQ LEDEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT 60
DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFKGPAEI LSLNNLMVSK IWTPDTFFRN 120
GKKSIAHNMT TPNKLFRLMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP 180
KTEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM 240
GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 300
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QSQKAERQAQ TAATPPVAKS KASESLQAEI 360
VVHSDSKYHL KKRISSLTLP IVPSSEASKA LSRTPILKST PVSPPLLLPA TGGTSKIDQY 420
SRILFPVAFA GFNLVYWIVY LSKDTMEVSS TVE 453 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. GO:0004890; F:GABA-A receptor activity; IEA:InterPro. GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |