UniProt Accession

 GCH1_BACSU; P19465 

Genbank Protein ID

 M37320; M80245; AL009126; X52418 

Genbank Nucleotide ID

 AAA22615.1; AAA20852.1; CAB14194.1 

Protein Name

 GTP cyclohydrolase 1 

Protein Synonyms/Alias

 GTP cyclohydrolase I; GTP-CH-I 

Gene Name

 folE 

Gene Synonyms/Alias

 mtrA; BSU22780 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
105	GKVTGLSKLARAVEA	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

  

Sequence Annotation

 METAL 78 78 Zinc (By similarity).
 METAL 81 81 Zinc (By similarity).
 METAL 150 150 Zinc (By similarity).  

Keyword

 Complete proteome; GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding; One-carbon metabolism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 190 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003934; F:GTP cyclohydrolase I activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006730; P:one-carbon metabolic process; IEA:HAMAP.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:HAMAP. 

Interpro

 IPR001474; GTP_CycHdrlase_I.
 IPR020602; GTP_CycHdrlase_I/CN_OxRdtase.
 IPR018234; GTP_CycHdrlase_I_CS. 

Pfam

 PF01227; GTP_cyclohydroI 

SMART

  

PROSITE

 PS00859; GTP_CYCLOHYDROL_1_1
 PS00860; GTP_CYCLOHYDROL_1_2 

PRINTS