UniProt Accession

 PRO1B_ACACA; Q95VF7; P07763 

Genbank Protein ID

 AF414696 

Genbank Nucleotide ID

 AAL07495.1 

Protein Name

 Profilin-1B 

Protein Synonyms/Alias

 Acidic profilin IB; Profilin IB 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Acanthamoeba castellanii (Amoeba) 

NCBI Taxa ID

 5755 

Lysine Modification

Position	Peptide	Type	References
104	LVGVYNEKIQPGTAA	methylation	[1]

Reference

 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. 

Sequence Annotation

 REGION 2 36 Actin-binding (Potential).
 BINDING 116 116 Actin.
 MOD_RES 104 104 N6,N6,N6-trimethyllysine.  

Keyword

 3D-structure; Actin-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing; Methylation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 

Interpro

 IPR027310; Profilin_CS.
 IPR005455; Profilin_eukaryotes/bac. 

Pfam

 PF00235; Profilin 

SMART

 SM00392; PROF 

PROSITE

 PS00414; PROFILIN 

PRINTS

 PR00392; PROFILIN.
 PR01640; PROFILINPLNT.