UniProt Accession

 RL13A_RAT; P35427 

Genbank Protein ID

 X68282 

Genbank Nucleotide ID

 CAA48343.1 

Protein Name

 60S ribosomal protein L13a 

Protein Synonyms/Alias

  

Gene Name

 Rpl13a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
103	QAALERLKVLDGIPP	acetylation	[1]
114	GIPPPYDKKKRMVVP	ubiquitination	[2]
125	MVVPAALKVVRLKPT	acetylation	[1]
159	VTATLEEKRKEKAKI	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 191 191 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0005840; C:ribosome; NAS:RGD.
 GO:0003735; F:structural constituent of ribosome; NAS:RGD.
 GO:1901194; P:negative regulation of formation of translation preinitiation complex; ISS:UniProtKB.
 GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR005822; Ribosomal_L13.
 IPR023563; Ribosomal_L13_CS.
 IPR023564; Ribosomal_L13_dom.
 IPR005755; Ribosomal_L13_euk/arc. 

Pfam

 PF00572; Ribosomal_L13 

SMART

  

PROSITE

 PS00783; RIBOSOMAL_L13 

PRINTS