UniProt Accession

 SCRB1_HUMAN; Q8WTV0; Q14016; Q52LZ5; Q6KFX4 

Genbank Protein ID

 Z22555; AF515445; BC022087; CH471054; BC080647; BC093732; BC112037 

Genbank Nucleotide ID

 CAA80277.1; AAQ08185.1; EAW98459.1; AAH80647.1; AAH93732.1; AAI12038.1 

Protein Name

 Scavenger receptor class B member 1 

Protein Synonyms/Alias

 SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD36 

Gene Name

 SCARB1 

Gene Synonyms/Alias

 CD36L1; CLA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
184	GEIMWGYKDPLVNLI	ubiquitination	[1]
288	RSMKLMYKESGVFEG	ubiquitination	[1]
484	SKKGSKDKEAIQAYS	ubiquitination	[1, 2, 3]
500	SLMTSAPKGSVLQEA	ubiquitination	[1]
508	GSVLQEAKL******	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). 

Sequence Annotation

 CARBOHYD 102 102 N-linked (GlcNAc...).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 255 255 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 330 330 N-linked (GlcNAc...).
 CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
 DISULFID 251 384 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Membrane; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 552 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; TAS:BHF-UCL.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0005545; F:1-phosphatidylinositol binding; TAS:BHF-UCL.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0070506; F:high-density lipoprotein particle receptor activity; IDA:BHF-UCL.
 GO:0001530; F:lipopolysaccharide binding; IDA:BHF-UCL.
 GO:0001875; F:lipopolysaccharide receptor activity; IDA:BHF-UCL.
 GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL.
 GO:0001786; F:phosphatidylserine binding; ISS:BHF-UCL.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0051856; P:adhesion to symbiont; IMP:BHF-UCL.
 GO:0006702; P:androgen biosynthetic process; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0006707; P:cholesterol catabolic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; ISS:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.
 GO:0070508; P:cholesterol import; ISS:BHF-UCL.
 GO:0032497; P:detection of lipopolysaccharide; IDA:BHF-UCL.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; ISS:BHF-UCL.
 GO:0006629; P:lipid metabolic process; TAS:Reactome.
 GO:0015920; P:lipopolysaccharide transport; IDA:BHF-UCL.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0034383; P:low-density lipoprotein particle clearance; ISS:BHF-UCL.
 GO:0015914; P:phospholipid transport; ISS:BHF-UCL.
 GO:0010886; P:positive regulation of cholesterol storage; IDA:BHF-UCL.
 GO:0010595; P:positive regulation of endothelial cell migration; TAS:BHF-UCL.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:BHF-UCL.
 GO:0043654; P:recognition of apoptotic cell; IDA:BHF-UCL.
 GO:0050764; P:regulation of phagocytosis; IC:BHF-UCL.
 GO:0010899; P:regulation of phosphatidylcholine catabolic process; ISS:BHF-UCL.
 GO:0043691; P:reverse cholesterol transport; IEP:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.
 GO:0042060; P:wound healing; TAS:BHF-UCL. 

Interpro

 IPR002159; CD36.
 IPR005428; CD36_antigen. 

Pfam

 PF01130; CD36 

SMART

  

PROSITE

  

PRINTS

 PR01610; CD36ANTIGEN.
 PR01609; CD36FAMILY.