CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 98 
Protein Synonyms/Alias
 Zinc finger protein 739; Zinc finger protein F7175 
Gene Name
 ZNF98 
Gene Synonyms/Alias
 ZNF739 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
245YKCEECGKAFNRLSHubiquitination[1, 2, 3]
351HTGEKFYKCEECGKAubiquitination[2, 3]
519HTGEKPYKCEECGKAubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 13 84 KRAB.
 ZN_FING 182 204 C2H2-type 1.
 ZN_FING 210 232 C2H2-type 2.
 ZN_FING 238 260 C2H2-type 3.
 ZN_FING 266 288 C2H2-type 4.
 ZN_FING 294 316 C2H2-type 5.
 ZN_FING 322 344 C2H2-type 6.
 ZN_FING 350 372 C2H2-type 7.
 ZN_FING 378 400 C2H2-type 8.
 ZN_FING 406 428 C2H2-type 9.
 ZN_FING 434 456 C2H2-type 10.
 ZN_FING 462 484 C2H2-type 11.
 ZN_FING 490 512 C2H2-type 12.
 ZN_FING 518 540 C2H2-type 13.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MPGPLGSLEM GVLTFRDVAL EFSLEEWQCL DTAQQNLYRN VMLENYRNLV FVGIAASKPD 60
LITCLEQGKE PWNVKRHEMV TEPPVVYSYF AQDLWPKQGK KNYFQKVILR TYKKCGRENL 120
QLRKYCKSMD ECKVHKECYN GLNQCLTTTQ NKIFQYDKYV KVFHKFSNSN RHKIGHTGKK 180
SFKCKECEKS FCMLSHLAQH KRIHSGEKPY KCKECGKAYN EASNLSTHKR IHTGKKPYKC 240
EECGKAFNRL SHLTTHKIIH TGKKPYKCEE CGKAFNQSAN LTTHKRIHTG EKPYKCEECG 300
RAFSQSSTLT AHKIIHAGEK PYKCEECGKA FSQSSTLTTH KIIHTGEKFY KCEECGKAFS 360
RLSHLTTHKR IHSGEKPYKC EECGKAFKQS STLTTHKRIH AGEKFYKCEV CSKAFSRFSH 420
LTTHKRIHTG EKPYKCEECG KAFNLSSQLT THKIIHTGEK PYKCEECGKA FNQSSTLSKH 480
KVIHTGEKPY KCEECGKAFN QSSHLTTHKM IHTGEKPYKC EECGKAFNNS SILNRHKMIH 540
TGEKLYKPES CNNACDNIAK ISKYKRNCAG EK 572 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS