UniProt Accession

 FAD1_MOUSE; Q8R123; Q3TSN6; Q8BXQ1 

Genbank Protein ID

 AK044501; AK161929; BC009152; BC025817; BC046769 

Genbank Nucleotide ID

 BAC31952.1; BAE36639.1; AAH09152.2; AAH25817.1; AAH46769.1 

Protein Name

 FAD synthase 

Protein Synonyms/Alias

 FAD pyrophosphorylase; FMN adenylyltransferase; Flavin adenine dinucleotide synthase; Molybdenum cofactor biosynthesis protein-like region; FAD synthase region 

Gene Name

 Flad1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
273	KAGEAVYKLAESGSC	ubiquitination	[1]
283	ESGSCLGKKVAGALQ	acetylation	[2, 3]
283	ESGSCLGKKVAGALQ	succinylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (By similarity). 

Sequence Annotation

 REGION 19 110 Molybdenum cofactor biosynthesis protein-
 REGION 303 460 FAD synthase.
 MOD_RES 468 468 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; FAD; FMN; Nucleotide-binding; Nucleotidyltransferase; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003919; F:FMN adenylyltransferase activity; IEA:EC.
 GO:0006747; P:FAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:InterPro. 

Interpro

 IPR012183; FAD_synth_Mopterin-bd.
 IPR001453; Mopterin-bd_dom.
 IPR002500; PAPS_reduct.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF00994; MoCF_biosynth
 PF01507; PAPS_reduct 

SMART

 SM00852; MoCF_biosynth 

PROSITE

  

PRINTS