UniProt Accession

 B4DPY6_HUMAN; B4DPY6 

Genbank Protein ID

 AC002080; AC002543; AC004416; AK298552 

Genbank Nucleotide ID

 BAG60748.1 

Protein Name

 Hepatocyte growth factor receptor 

Protein Synonyms/Alias

 cDNA FLJ51931, highly similar to Hepatocyte growth factor receptor (EC 2.7.10.1) 

Gene Name

 MET 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	LVVLPYMKHGDLRNF	ubiquitination	[1, 2]
49	ETHNPTVKDLIGFGL	ubiquitination	[2, 3]
60	GFGLQVAKGMKYLAS	ubiquitination	[1, 2]
63	LQVAKGMKYLASKKF	ubiquitination	[2]
89	LDEKFTVKVADFGLA	ubiquitination	[1, 2]
102	LARDMYDKEYYSVHN	ubiquitination	[1, 2, 3]
110	EYYSVHNKTGAKLPV	ubiquitination	[1, 2, 3]
118	TGAKLPVKWMALESL	ubiquitination	[2]
188	PLYEVMLKCWHPKAE	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Receptor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005008; F:hepatocyte growth factor-activated receptor activity; IEA:Compara.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0014812; P:muscle cell migration; IEA:Compara.
 GO:0051450; P:myoblast proliferation; IEA:Compara.
 GO:0014902; P:myotube differentiation; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0010828; P:positive regulation of glucose transport; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 

Pfam

 PF07714; Pkinase_Tyr 

SMART

 SM00219; TyrKc 

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 

PRINTS

 PR00109; TYRKINASE.