CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein N2 
Protein Synonyms/Alias
 Human T-cell leukemia virus enhancer factor 
Gene Name
 FOXN2 
Gene Synonyms/Alias
 HTLF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
422GSLISTAKTQNQKQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Binds to the purine-rich region in HTLV-I LTR. 
Sequence Annotation
 DNA_BIND 112 208 Fork-head.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 431 AA 
Protein Sequence
MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN 60
WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL 120
IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV 180
NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA 240
AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 300
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD 360
PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST 420
AKTQNQKQRK K 431 
Gene Ontology
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0009888; P:tissue development; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.