UniProt Accession

 CYC_BOVIN; P62894; P00006; Q2KJD4 

Genbank Protein ID

 BC105397 

Genbank Nucleotide ID

 AAI05398.1 

Protein Name

 Cytochrome c 

Protein Synonyms/Alias

  

Gene Name

 CYCS 

Gene Synonyms/Alias

 CYC 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
6	**MGDVEKGKKIFVQ	acetylation	[1]
8	MGDVEKGKKIFVQKC	acetylation	[1]
9	GDVEKGKKIFVQKCA	acetylation	[1]
14	GKKIFVQKCAQCHTV	acetylation	[1]
23	AQCHTVEKGGKHKTG	acetylation	[1, 2]
26	HTVEKGGKHKTGPNL	acetylation	[1]
28	VEKGGKHKTGPNLHG	acetylation	[1]
40	LHGLFGRKTGQAPGF	acetylation	[1]
54	FSYTDANKNKGITWG	acetylation	[1]
56	YTDANKNKGITWGEE	acetylation	[1]
73	MEYLENPKKYIPGTK	acetylation	[1]
74	EYLENPKKYIPGTKM	acetylation	[1]
80	KKYIPGTKMIFAGIK	acetylation	[1]
87	KMIFAGIKKKGERED	acetylation	[1]
88	MIFAGIKKKGEREDL	acetylation	[1]
89	IFAGIKKKGEREDLI	acetylation	[1, 3]
100	EDLIAYLKKATNE**	acetylation	[1]
101	DLIAYLKKATNE***	acetylation	[1]

Reference

 [1] Comparison of the binding sites on cytochrome c for cytochrome c oxidase, cytochrome bc1, and cytochrome c1. Differential acetylation of lysyl residues in free and complexed cytochrome c.
 Rieder R, Bosshard HR.
 J Biol Chem. 1980 May 25;255(10):4732-9. [PMID: 6246081]
 [2] Studies on chemically modified cytochrome c. I. The acetylated cytochrome c.
 Wada K, Okunuki K.
 J Biochem. 1968 Nov;64(5):667-81. [PMID: 4303654]
 [3] Partial acetylation of lysine residues improves intraprotein cross-linking.
 Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW.
 Anal Chem. 2008 Feb 15;80(4):951-60. [PMID: 18201069] 

Functional Description

 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. 

Sequence Annotation

 METAL 19 19 Iron (heme axial ligand).
 METAL 81 81 Iron (heme axial ligand).
 BINDING 15 15 Heme (covalent).
 BINDING 18 18 Heme (covalent).
 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 49 49 Phosphotyrosine.
 MOD_RES 98 98 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding; Mitochondrion; Phosphoprotein; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR002327; Cyt_c_1A/1B.
 IPR009056; Cyt_c_dom.
 IPR003088; Cyt_c_I. 

Pfam

 PF00034; Cytochrom_C 

SMART

  

PROSITE

 PS51007; CYTC 

PRINTS

 PR00604; CYTCHRMECIAB.