CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013563
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome biogenesis factor 1 
Protein Synonyms/Alias
 Peroxin-1 
Gene Name
 Pex1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
234ASNGRDPKVPGGPLKacetylation[1]
348KQQQDKSKQGVLLPDubiquitination[2]
356QGVLLPDKEKQLSKSubiquitination[2]
410LELLHRGKVWIPDDLubiquitination[2]
454QPRENLPKDVNEETIubiquitination[2]
615TFAKAICKEAQDTLDubiquitination[2]
631RVETVDCKALRGKRLubiquitination[2]
817LTTSDFQKALRGFLPubiquitination[2]
842PRDLGWDKIGGLHEVubiquitination[2]
914KGPELLSKYIGASEQubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity). 
Sequence Annotation
 NP_BIND 600 607 ATP (Potential).
 NP_BIND 882 889 ATP (Potential).
 MOD_RES 1210 1210 Phosphoserine (By similarity).
 MOD_RES 1212 1212 Phosphoserine.
 CROSSLNK 834 834 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Lipid-binding; Membrane; Nucleotide-binding; Peroxisome; Peroxisome biogenesis; Peroxisome biogenesis disorder; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1284 AA 
Protein Sequence
MWSSDRLAGA GSGGAVVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVA SDHQPTYLSW 60
VEGRHFNDQS ENVAEINRQV GQKLGLSSGD QVFLRPCSHV VSCQQVEVEP LSADDWEILE 120
LHAISLEQHL LDQIRIVFPK AVVPIWVDQQ TYIFIQIVTL MPAAPYGRLE TNTKLLIQPK 180
TRQAKESTFP KEGDAHGQVH SYGREQKGLS KELQTRQLHT NSEGITASNG RDPKVPGGPL 240
KPSWWAVLGS MLSFGPDSKQ ESAWGSLELG AFKNMQSQAA PLEGTFRVCQ VQPPSARTTT 300
ATSVFHKHCT AHVFPWDQEY FDVEPSFTVT YGKLVKLHSP KQQQDKSKQG VLLPDKEKQL 360
SKSPDHKQIS SNRSEEAAEA CVLKVVWNGL EELKNATEFT ESLELLHRGK VWIPDDLRKR 420
LNIEMHAVVR ITPLETTPKI PRSLKLQPRE NLPKDVNEET IKTVFSSWVQ QSATTMLPLV 480
ISKEERIKLE IKDGLREFSL STVHSQEKEK EEGKTVFVLS SILLQKISVQ VLLEPMIKEE 540
QSAEIDFLLP SLTLSSLGGV SALGASAMEH ITHSLLGRPL SRQLMALVAG LRNGALLITG 600
GKGSGKSTFA KAICKEAQDT LDARVETVDC KALRGKRLES IQKALEVAFS EAAWRQPSVI 660
LLDDLDLIAG LPSVPEQEHS PEAVQSQRLA HALNDMIKEF VSTGSLVALI ATSQLQQSLH 720
PSLVSAQGIH TFQCVQHLQP PNPEQRCEIL HSVVKNKLGC DISNFPDLDL QCIAKDTEAF 780
VARDFTVLVD RAIHSSLSRQ HSSSREDLTL TTSDFQKALR GFLPASLRNV NLHKPRDLGW 840
DKIGGLHEVR QILMDTIQLP AKYPELFANL PIRQRTGILL YGPPGTGKTL LAGVVARESG 900
MNFISIKGPE LLSKYIGASE QAVRDVFIRA QAAKPCILFF DEFESIAPRR GHDNTGVTDR 960
VVNQLLTQLD GVEGLQGVYV LAATSRPDLI DPALLRPGRL DKCVYCPPPD QVSRLEILTV 1020
LSKSLALADD VDLQHVASVT DSFTGADLKA LLYNAQLEAL QGRLLPSGLP DGGSSSDSDL 1080
SLSSMVFLNH SSGSDDSAGD GECGLEQSLL SLEMSEILPD ESKFNMYRLY FGSSYESELG 1140
NGTPSDLSSH CLSAPSSVTQ DLPAAPGKDP LFTQHPVFRT PSQEGCQDLT QEQRDQLRAE 1200
ISIIKGRYRS QSGEDESLNQ PGPIKTTFAI SQAHLMTALA HTRPSISEDE GKEFAELYEN 1260
FQNPKKRKNQ SGTVFRTGQK VTLA 1284 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042623; F:ATPase activity, coupled; IEA:Compara.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0060152; P:microtubule-based peroxisome localization; IEA:Compara.
 GO:0016558; P:protein import into peroxisome matrix; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR009010; Asp_de-COase-like_dom.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase.
 IPR015343; Peroxisome_synth_fac_1_a/b.
 IPR015342; PEX-1N.
 IPR025653; Pex1. 
Pfam
 PF00004; AAA
 PF09262; PEX-1N
 PF09263; PEX-2N 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS